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Autor:
Elaine Soares Coimbra, Vinicio T.S. Coelho, Patrícia A.F. Ribeiro, Guilherme R. Pereira, Guilherme Firmo De Matos, Luísa Perin, Pedro Henrique De Almeida Simões Neves, Eduardo A.F. Coelho, Grasiele S.V. Tavares, Andreza Cristina Gomes Ferreira, Daniel Dias, Débora V.C. Mendonça, Fernanda Ludolf, Daniela P. Lage, Luciana M.R. Antinarelli, Tauane G. Soyer, Miguel A. Chávez-Fumagalli
Publikováno v:
Experimental Parasitology. 199:30-37
The treatment against leishmaniasis presents problems, since the currently used drugs are toxic and/or have high costs. In addition, parasite resistance has increased. As a consequence, in this study, a chloroquinolin derivative, namely 7-chloro-N,N-
Autor:
Tanmoy Dutta, Joydip Ghosh, Krishnendu Acharya, Aritri Dutta, Chiranjib Pal, Sirin Salma Sultana, Suvadip Mallick, Debarati Mukherjee, Sondipon Chakraborty, Soumen Bhattacharya, Somaditya Dey, Narayan Ghorai, Somanjana Khatua, Soumitra Paloi
Publikováno v:
Experimental Parasitology. 192:73-84
The current study was designed to assess the anti-leishmanial effect of a semi-purified fraction of wild mushroom Grifola frondosa against Leishmania donovani, in vitro. A total of five extracts from three wild mushrooms [Grifola frondosa (family, Me
Autor:
Bahareh Mirzaalizadeh, Ahmad Daryani, Mahbobeh Montazeri, Mohammad Ali Ebrahimzadeh, Mohammad Taghi Rahimi, Shahabeddin Sarvi, Saeed Mehrzadi, Zahra Mirabediny, Monireh Golpour, Mehryar Zargari, Mehdi Sharif
Publikováno v:
Experimental Parasitology. 192:6-11
Toxoplasmosis is a worldwide disease caused by the protozoan parasite Toxoplasma gondii (T. gondii), which is most commonly treated by pyrimethamine and sulfadiazine. However, this treatment presents several adverse side effects; Thus, new drugs with
Autor:
Alessandra M. Silva, Débora V.C. Mendonça, Luciana M.R. Antinarelli, Elaine Soares Coimbra, João A. Oliveira-da-Silva, Camila S. Freitas, Maria Victoria Humbert, Bruno Mendes Roatt, Eduardo A.F. Coelho, Rory Cristiane Fortes de Brito, Vívian T. Martins, Miguel A. Chávez-Fumagalli, Fernanda F. Ramos, Daniela P. Lage, Grasiele S.V. Tavares, Fernanda Ludolf, Thiago A.R. Reis, Rafaella R Costa, Amanda S. Machado
Publikováno v:
Experimental parasitology. 221
Treatment for visceral leishmaniasis (VL) is hindered mainly by the toxicity and/or high cost of therapeutic drugs. In addition, parasite resistance has been registered. Thus, there is an urgent need for the identification of novel, effective and low
Autor:
Subhash Chander, Rosa M. Reguera, Murugesan Sankaranarayanan, Rafael Balaña-Fouce, M. Yolanda Pérez-Pertejo, Ruben Carbajo-Andres, Penta Ashok, Kondapalli Venkata Gowri Chandra Sekhar
Publikováno v:
Experimental Parasitology. 189:49-60
In the present study, anti-leishmanial evaluation of twenty four structurally diverse compounds based on benzopiperidine, benzopyridine and phenylpiperazine nucleuses against Leishmania infantum has been reported. Cytotoxicity studies of all the comp
Autor:
Hemanta K. Majumder, Amit Roy, Siddhartha Kumar Bhaumik, Joydeep Paul, Sudeshna Sawoo, Manoj Kumar Singh, Subir Karmakar
Publikováno v:
Experimental Parasitology. 175:8-20
In vitro and in vivo anti-leishmanial efficacy of copper salisylaldoxime (CuSAL), a transition metal complex, was evaluated and the underlying mechanism was studied. In vitro studies revealed that 30 μM of CuSAL causes 96% reduction in parasite burd
Autor:
Jalal Babaie, Samira Amiri, Majid Golkar, Alireza Vatanara, Reyhaneh Mohabati, Mojgan Allahyari, Ahmad Reza Esmaeili Rastaghi, Mehdi Mahdavi
Publikováno v:
Experimental Parasitology. 170:236-246
There is still no human vaccine against Toxoplasma gondii (T. gondii) , as one of the most successful parasites. In present study, we designed a subunit vaccine composed of recombinant SAG1 (rSAG1) and recombinant GRA2 (rGRA2) proteins. In order to i
Publikováno v:
Experimental Parasitology. 170:73-81
The mechanisms regulating the induction of protective immunity against blood-stage malaria remain unclear. Resistant DBA/2 mouse develops a higher Th1 response compared with a susceptible BALB/c strain during Plasmodium yoelii (Py) infection. It is k
Autor:
Letícia Martins dos Reis Lage, Mariana C. Duarte, Rachel Oliveira Castilho, Bruno Mendes Roatt, Débora V.C. Mendonça, Eduardo A.F. Coelho, André Augusto Gomes Faraco, Fernanda Ludolf, Jose Mario Barichello, Daniel Menezes-Souza, Miguel A. Chávez-Fumagalli, Daniela P. Lage, Carlos Alberto Pereira Tavares
Publikováno v:
Repositório Institucional da UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
In the present study, a Poloxamer 407-based amphotericin B (AmpB)-containing polymeric micelles system (AmpB/M) was employed in the treatment of Leishmania amazonensis-infected BALB/c mice. Initially, the in vitro antileishmanial activity (IC50 value
Autor:
Rafael C. Costa, Paulo César Maiorka, Lucas Emanuel dos Santos Mesquita, Dennis Albert Zannato, Leonardo Pereira Mesquita, Cristina de Oliveira Massoco Salles Gomes, Ivam Moreira de Oliveira, Daniel Arrais Biihrer, Mary Suzan Varaschin
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Goats are frequently described as an intermediate host for the protozoan Neospora caninum, manifesting the disease mainly by recurrent abortions with placentitis and encephalitis in fetuses. Several reports of natural and experimental infections in c