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Publikováno v:
Experimental Parasitology. 202:15-21
Toxoplasma gondii is an opportunistic zoonotic protozoan that exceeds neurological and congenital impact sequence to reactivating latent toxoplasmosis especially under immunosuppression. Sex-associated hormones influence the severity of Toxoplasma in
Autor:
Patsharaporn T. Sarasombath, Patcharin Priyavoravong, Sumat Loimek, Hathai Nochot, Sirichit Wongkamchai
Publikováno v:
Experimental Parasitology. 200:73-78
Objective The aim of this study was to evaluate the efficacy of oral doxycycline treatment for Brugia malayi as measured by microfilarial and filarial DNA clearance in naturally infected domestic cats. Methods This study included 8 domestic cats that
Publikováno v:
Experimental Parasitology. 199:1-8
Schistosomiasis remains a severe problem of public health in developing countries. The development of resistance to praziquantel (PZQ) has justified the search for new alternative chemotherapies with new formulations, more effective, and without adve
Autor:
Mona Kilany, Hamed A. Ghramh, Aly Alshehri, Essam H. Ibrahim, Saad M. Dajem, Ibrahim Aly, Rabab S. Hamad, Gehan ELnain
Publikováno v:
Experimental Parasitology. 194:53-59
Schistosomiasis is a fatal disease that has a negative impact on health and economics. Praziquantel (PZQ) is the drug of choice for schistosomiasis treatment, but it has no prophylactic effect; therefore, vaccination is an essential requirement in sc
Autor:
Bahareh Mirzaalizadeh, Ahmad Daryani, Mahbobeh Montazeri, Mohammad Ali Ebrahimzadeh, Mohammad Taghi Rahimi, Shahabeddin Sarvi, Saeed Mehrzadi, Zahra Mirabediny, Monireh Golpour, Mehryar Zargari, Mehdi Sharif
Publikováno v:
Experimental Parasitology. 192:6-11
Toxoplasmosis is a worldwide disease caused by the protozoan parasite Toxoplasma gondii (T. gondii), which is most commonly treated by pyrimethamine and sulfadiazine. However, this treatment presents several adverse side effects; Thus, new drugs with
Autor:
Jianqiang Zhang, Quan Gong, Hao Nie, Gang Li, Ting Zheng, Yanxiang Zhang, Qianglin Chen, Bing Zheng, Chao Wang, Fei Yang, Hui Chen
Publikováno v:
Experimental Parasitology. 231:108171
Schistosomiasis is a prevalent zoonotic parasitic disease caused by schistosomes. Its main threat to human health is hepatic granuloma and fibrosis due to worm eggs. Praziquantel remains the first choice for the treatment of schistosomiasis but has l
Autor:
Auwal Adamu, Muhammad Sani Abubakar, Mohammed Auwal Ibrahim, Mohammed Aliyu Usman, Fadilat Isah Usman, Abdulmalik Abdullahi Salman
Publikováno v:
Experimental parasitology. 224
The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condi
Autor:
Alessandra M. Silva, Débora V.C. Mendonça, Luciana M.R. Antinarelli, Elaine Soares Coimbra, João A. Oliveira-da-Silva, Camila S. Freitas, Maria Victoria Humbert, Bruno Mendes Roatt, Eduardo A.F. Coelho, Rory Cristiane Fortes de Brito, Vívian T. Martins, Miguel A. Chávez-Fumagalli, Fernanda F. Ramos, Daniela P. Lage, Grasiele S.V. Tavares, Fernanda Ludolf, Thiago A.R. Reis, Rafaella R Costa, Amanda S. Machado
Publikováno v:
Experimental parasitology. 221
Treatment for visceral leishmaniasis (VL) is hindered mainly by the toxicity and/or high cost of therapeutic drugs. In addition, parasite resistance has been registered. Thus, there is an urgent need for the identification of novel, effective and low
Autor:
Cinthia Melazzo de Andrade, Dionatan Teixeira de Oliveira, Marjorie de Giacommeti, Silvia Gonzalez Monteiro, Ana Martiele Engelmann, João Cândido Pillar Mayer, Luciano Dornelles, Antônio Francisco Igor Magalhães de Matos, Litiérria Razia Garzon, Matheus D. Baldissera, Letícia dos Santos Petry
Publikováno v:
Experimental parasitology.
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this dis
Autor:
Bruno Gottstein, Reto Rufener, Nelson Marreros, Britta Lundström-Stadelmann, Andrew Hemphill, Junhua Wang
Publikováno v:
Wang, Junhua; Marreros, Nelson; Rufener, Reto; Hemphill, Andrew; Gottstein, Bruno; Lundström-Stadelmann, Britta (2020). Short communication: Efficacy of albendazole in Echinococcus multilocularis-infected mice depends on the functional immunity of the host. Experimental parasitology, 219, p. 108013. Elsevier 10.1016/j.exppara.2020.108013
Alveolar echinococcosis (AE) is a deadly parasitic disease that requires lifelong treatment with albendazole. Development of host immunity is pivotal with regard to the clinical outcome of AE, but its influence on conventional albendazole treatment i