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of 4
pro vyhledávání: '"Doron Merkler"'
Autor:
Ricarda Diem, Ivana Gadjanski, Mathias Bähr, Iris Demmer, Sarah K. Williams, Christine Stadelmann, Muriel B. Sättler, Katharina Maier, Doron Merkler
Publikováno v:
Experimental Neurology. 201:172-181
Interferon-beta-1a (IFN-beta-1a) is an approved treatment for multiple sclerosis (MS). It improves the disease course by reducing the relapse rate as well as the persistent neurological deficits. Recent MRI and post-mortem studies revealed that neuro
Autor:
Marco Prinz, Florian Klinker, Wolfgang Brück, Doron Merkler, Hauke Schmidt, Jenni Raasch, Sandra Krauss
Publikováno v:
Experimental Neurology, Vol. 216, No 2 (2009) pp. 306-311
The type I interferons, interferon-beta and alpha (IFN-beta, IFN-alpha), are widely used for the treatment of autoimmune demyelination in the central nervous system (CNS). Their effects on de- and remyelination through the broadly expressed type I IF
Autor:
David Liebetanz, Doron Merkler
Publikováno v:
Experimental neurology. 202(1)
Feeding of copper chelator cuprizone induces reversible demyelination, predominantly of the corpus callosum in C57/Bl6 mice. With the availability of knockout and transgenic mice, this animal model of multiple sclerosis has increasingly attracted sci
Autor:
Christine Stadelmann, Doron Merkler, Ina Boger, Mathias Bähr, Iris Demmer, Ricarda Diem, Muriel B. Sättler
Publikováno v:
Experimental neurology. 193(1)
In patients with multiple sclerosis (MS), non-remitting deficits are mainly caused by axonal and neuronal damage. We demonstrated previously that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in rats prov