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Autor:
Marzia Menegatti, Fabrizia Bamonti Catena, Umberto Gianelli, Federica Savi, Elisa Fermo, Nicola Stefano Fracchiolla, Agostino Cortelezzi, S. Lonati, Claudia Vener, Franca Radaelli, Cristina Novembrino, Giorgio Lambertenghi Deliliers
Publikováno v:
Experimental Hematology. 38:1058-1065
To determine if increased cell turnover in chronic myeloproliferative disorders can lead to hyperhomocysteinemia as a result of folate and/or cobalamin depletion, and contribute to oxidative stress.The clinical role of oxidative stress was investigat
Autor:
Jacob M. Rowe, Maty Tzukerman, Neta Pery, Shlomit Yehudai-Resheff, Tsila Zuckerman, Ehud Shapiro, Liran I. Shlush, Roni Shouval, Shahnaz Ali
Publikováno v:
Experimental hematology. 42(6)
FMS-like tyrosine kinase 3 receptor–internal tandem duplication (FLT3-ITD) commonly occurs in acute myeloid leukemia and is considered rare in acute lymphocytic leukemia. Acute leukemia has poor prognosis, mainly due to relapse. Standard FLT3-ITD d
Autor:
M. J. Citores, José A. García-Marco, Juan A. Vargas, Mercedes Villarreal, Raquel Castejón, Silvia Rosado
Publikováno v:
Experimental hematology. 38(3)
Despite a fludarabine-based treatment is the first choice of therapy in chronic lymphocytic leukemia (CLL), not all patients achieve a partial or complete response and some of them develop autoimmune manifestations. The aim of this study was to evalu
Autor:
Tiziano Barbui, Vittoria Guerini, Anna Falanga, Donatella Balducci, Alfonso Vignoli, Marina Marchetti, Laura Russo
Publikováno v:
Experimental hematology. 35(5)
This article evaluates patients with essential thrombocythemia (ET) to determine whether the V617F mutation in the JAK2 gene affects platelet hemostatic and adhesive molecules, platelet-polymorphonuclear leukocyte (PMN) interactions, and PMN-activati
Autor:
Koichi Akashi, Yoshikane Kikushige, Shinichi Mizuno, Koji Kato, Goichi Yoshimoto, Katsuto Takenaka, Noriko Goto, Hiromi Iwasaki, Taro Tochigi, Junichiro Yuda, Takahiro Shima, Toshihiro Miyamoto
Publikováno v:
Experimental Hematology. 42:955-965.e5
The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively. Here we show that in t(8;21) acute myeloge
Publikováno v:
Experimental hematology. 28(2)
Objective Essential mixed cryoglobulinemia (EMC) type II is associated with hepatitis C virus (HCV) in 90% of the patients with this disorder. A significant subset of these patients is at risk to develop non-Hodgkin lymphoma (NHL). The objective of t