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Autor:
Anna Puiggros, Blanca Espinet, Ana Ferrer, María Rodríguez-Rivera, Pau Abrisqueta, Florencia Palacios, Lara Nonell, Alexandre Calon, Gonzalo Blanco, Nicholas Chiorazzi, Pui Yan Chiu, Xavier Calvo, Magdalena Arnal, Eugenia Abella, Kanti R. Rai, Eva Gimeno, Gerardo Ferrer, Francesc Bosch, Yasmine Kieso, Barbara Sherry, Eulàlia Puigdecanet
Publikováno v:
Exp Hematol
Several studies in chronic lymphocytic leukemia (CLL) patients have reported impaired immune cell functions, which contribute to tumor evasion and disease progression. However, studies on CLL-like monoclonal B-cell lymphocytosis (MBL) are scarce. In
Autor:
Xingxin Li, Jing Zhang, Min Wang, Peng Jin, Jinbo Huang, Jun Shi, Yu Lian, Yizhou Zheng, Neng Nie, Yingqi Shao, Meili Ge, Zhendong Huang
Publikováno v:
Experimental hematology. 77
The paroxysmal nocturnal hemoglobinuria (PNH) clone often presents in acquired bone marrow failure (aBMF), which is involved in more than half of aplastic anemia (AA) cases and about 10%-20% of myelodysplastic syndrome (MDS) cases. PNH clone expansio
Autor:
N Orru, Marianna Greco, Andrea Floris, Sandro Orru, Marzia Langiu, S Atzeni, Carlo Carcassi, Adriana Vacca, Giovanni Caocci, Roberto Littera, Giorgio La Nasa, Olga Mulas
Publikováno v:
Experimental Hematology. 41:424-431
Several recent reports suggest a possible role for killer immunoglobulin-like receptors (KIR) in the onset of chronic myeloid leukemia (CML) and response to therapy with tyrosine kinase inhibitors (TKIs). To explore this hypothesis, we studied KIRs a
Publikováno v:
Experimental hematology. 47
Aldehyde dehydrogenase (ALDH) activity is an established feature of primitive normal human hematopoietic cells, in which it has been associated with a high expression of the 1A1 isoform of ALDH. High ALDH 1A1 activity has been reported to also charac
Autor:
Shinji Nakao, Hiroyuki Maruyama, Seishi Ogawa, Hirohito Yamazaki, Koichi Kashiwase, Kana Maruyama, Yoshitaka Zaimoku, Aiko Sato-Otsubo, Takamasa Katagiri, Ken Ishiyama, Hidetoshi Inoko, Kohei Hosokawa, Takashi Shiina
Publikováno v:
Experimental hematology. 44(10)
To gain insight into the origin and clinical significance of leukocytes that lack human leukocyte antigen A (HLA-A) allele expression caused by a copy-number-neutral loss of heterozygosity in the short arm of chromosome 6 in patients with acquired ap
Autor:
Béatrice Gaugler, Jihane Frikeche, Marc Grégoire, Jacques Delaunay, Mohamad Mohty, Aline Clavert, Eolia Brissot
Publikováno v:
Experimental Hematology. 39:1056-1063
Recent evidence suggested that 5-azacytidine (5-aza) can impact important immune functions via epigenetic modifications, making it an attractive candidate for pharmacologic manipulation of the immune system. The aim of this work was to study the effe
Autor:
Andreas K. Klein, Olga V. Danilova, Arthur P. Rabinowitz, Brigitte T. Huber, Alexey V. Danilov, Jennifer R. Brown
Publikováno v:
Experimental Hematology. 38:1167-1177
Objective Dipeptidyl peptidase 2 (DPP2/DPP7) is a regulator of quiescence as inhibition of DPP2 results in apoptosis of resting, but not activated lymphocytes. The purpose of the present study was to investigate the prognostic value of DPP2 inhibitio
Autor:
Marzia Menegatti, Fabrizia Bamonti Catena, Umberto Gianelli, Federica Savi, Elisa Fermo, Nicola Stefano Fracchiolla, Agostino Cortelezzi, S. Lonati, Claudia Vener, Franca Radaelli, Cristina Novembrino, Giorgio Lambertenghi Deliliers
Publikováno v:
Experimental Hematology. 38:1058-1065
To determine if increased cell turnover in chronic myeloproliferative disorders can lead to hyperhomocysteinemia as a result of folate and/or cobalamin depletion, and contribute to oxidative stress.The clinical role of oxidative stress was investigat
Autor:
Helga Schmetzer, Christian Ries, Donato Santovito, Tanja Kroell, Virginia Egea, Christian Weber, Joerg Uwe Schmohl, Wishnu Sutanto, Thomas Guenther, Thomas Pitsch, Helmut R. Salih
Publikováno v:
Experimental hematology. 44(5)
With its ability to degrade extracellular matrix proteins and activate growth factors and cytokines, matrix metalloproteinase (MMP)-9 is an important regulator of cell function. Previously, we reported that myeloid leukemic cells express a unique 82k
Autor:
Keiya Ozawa, Yasushi Miyazaki, Jun Ota, Ruri Kaneda, Masao Tomonaga, Hiroyuki Mano, Shin-ichiro Fujiwara, Chizuko Tsutsumi, Koji Koinuma, Young Lim Choi, Madoka Ishikawa, Masuzu Ueda, Hiroyuki Kisanuki, Yoshihiro Yamashita
Publikováno v:
Experimental Hematology. 32:828-835
Objective Acute myeloid leukemia (AML) develops de novo or secondarily to either myelodysplastic syndrome (MDS) or anticancer treatment (therapy-related leukemia, TRL). Prominent dysplasia of blood cells is apparent in individuals with MDS-related AM