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Autor:
Emmanuelle Bourrat, Min Shen, Marine Madrange, Walid Beghdadi, Elodie Bal, Rihab Gazah, Ai Ching Lim, Jennifer E. Towne, Hervé Bachelez, Asma Smahi, Jason Douangpanya, Marie Tauber, Jean-Laurent Casanova
Publikováno v:
Experimental Dermatology. 28:1114-1117
The identification of loss-of-function mutations of the IL36RN gene encoding the interleukin-36 receptor antagonist (IL-36Ra) in generalized pustular psoriasis (GPP) emphasized the key role of this pathway in skin innate immunity and systemic inflamm