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Autor:
Qiuzhi Gao, Linjing Cui, Chao Huang, Zhihong Chen, Xin Wang, Shaodi Wen, Yuanyuan Zhao, Mei Wang, Bo Shen, Wei Zhu
Publikováno v:
Experimental cell research. 422(1)
CD276 has been studied in a variety of cancers and diseases, but its regulatory mechanisms in gastric cancer is still unclear. Mesenchymal stem cells (MSCs), one of the important members of tumor microenvironment, play an important role in the occurr
Publikováno v:
Experimental cell research. 422(1)
Colorectal cancer (CRC) is a common malignant tumor of digestive system. Its incidence rate and mortality rate ranks the third among all the malignant tumors. The objective of this study was to explore the role of β-catenin in the CRC progression. T
Publikováno v:
Experimental cell research. 419(2)
Oxygen deprivation is a key hallmark within solid tumours that contributes to breast-tumour pathophysiology. Under these conditions, neoplastic cells activate several genes, regulated by the HIF-1 transcription factor, which alters the tumour microen
Publikováno v:
Experimental cell research. 420(1)
Staphylococcus aureus causes subclinical mastitis; lipoteichoic acid (LTA) from S. aureus causes mastitis-like adverse effects on milk production by mammary epithelial cells (MECs). Here, we investigated the early effects of LTA from S. aureus on mou
Publikováno v:
Experimental cell research. 420(1)
CTP synthase (CTPS), a metabolic enzyme responsible for the de novo synthesis of CTP, can form filamentous structures termed cytoophidia, which are evolutionarily conserved from bacteria to humans. Here we used Schizosaccharomyces pombe to study the
Autor:
Saptarshi Sinha, Subhajit Chatterjee, Subarno Paul, Biswajit Das, Somya Ranjan Dash, Chinmay Das, Chanakya Nath Kundu
Publikováno v:
Experimental cell research. 420(1)
Although sensitization of BRCA-mutated, homologous recombination (HR)-deficient breast cancer cells through PARP inhibitor is widely studied, not much is known about the treatment of BRCA-wild-type, HR-proficient breast cancer. Here, we aim to invest
Publikováno v:
Experimental cell research. 421(2)
Leukemia is a type of blood cancer characterized by high genetic heterogeneity and fatality. While chemotherapy remains the primary form of treatment for leukemia, its effectiveness was profoundly diminished by the genetic heterogeneity and cytogenet
Publikováno v:
Experimental cell research. 421(2)
Aberrant ubiquitin-proteasome system (UPS) contributes to tumorigeneisis or drug resistance of Pancreatic Adenocarcinoma (PAAD). Previous studies have implicated the deubiquitinase UCHL5 was abnormally expressed in multiple malignancies. However, lit
Autor:
Xiaoxue Ma, Yiru Wang, Qi Liu, Baihe Han, Gang Wang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Mengyue Yang, Chun Xing, Jingbo Hou, Bo Yu
Publikováno v:
Experimental cell research. 421(2)
Vascular calcification (VC) is closely related to higher cardiovascular mortality and morbidity, and vascular smooth muscle cell (VSMC) switching to osteogenic-like cells is crucial for VC. LncRNA LEF1-AS1 promotes atherosclerosis and dental pulp ste
Publikováno v:
Experimental cell research. 421(1)
Cervical cancer is a major gynecological tumor worldwide. Unfortunately, the molecular mechanisms involved in cervical cancer tumorigenesis still requires more clarification. Lysophosphatidylcholine acyltransferase 1 (LPCAT1), an enzyme involved in p