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Autor:
Lei Liu, Lin Bao, Wen Jun Hu, Chang Fei Yuan, Yan Qu, Yao Ying Gao, Ze Yuan Ru, Guanghua Xu, Hong Mei Yang, Xiang Li, Xuanyu Chen, Hai Bin Xiao, Jun Wei Tong, Zheng Shuai Song, Ke Chen, Xiaoping Zhang, Zhi Yong Xiong, Ke Shan Wang, Hai Long Ruan, Wen Xiao, Qi Cao
Publikováno v:
Experimental Cell Research. 358:269-278
Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpres
Publikováno v:
Experimental Cell Research. 355:47-56
Clear Cell Renal Cell Carcinoma (CCRCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of more aggressive tumors. Investigation of Gas6-mediated Axl signaling in CCRCC and endothelial cells reveals a Suniti
Publikováno v:
Experimental Cell Research. 352:364-374
Lung cancer is the common cause of death from cancer, and most lung cancer patients die of metastasis. MicroRNAs (miRNAs) function as either oncogenes or tumor suppressors, playing crucial role not only in tumorigenesis, but also in tumor invasion an
Publikováno v:
Experimental Cell Research. 349:119-127
Epithelial-mesenchymal transition (EMT) is an important mechanism in cancer progression and malignancy including colorectal cancer (CRC). Importantly, inflammatory mediators are critical constituents of the local tumor environment and an intimate lin
Publikováno v:
Experimental cell research. 374(1)
MicroRNAs (miRNAs) regulate diverse cellular processes such as cell differentiation, proliferation and apoptosis. Mutation in miRNAs results in various pathological conditions such as inflammation, viral infections, neurodegeneration, and autoimmunit
Publikováno v:
Experimental Cell Research. 345:180-189
Local acidosis is one of the characteristic features of the cancer microenvironment. Many reports indicate that acidosis accelerates the proliferation and invasiveness of cancer cells. However, whether acidic conditions affect lymphatic metastasis is
Autor:
Jieyao Li, Yu Ping, Dongli Yue, Lifeng Li, Xinfeng Chen, Shasha Liu, Liping Wang, Yi Zhang, Bin Zhang, Zhen Zhang, Lan Huang, Yan Sun, Xiaojuan Shi
Publikováno v:
Experimental Cell Research. 336:141-149
Esophageal cancer is one of the most lethal solid malignancies. Mounting evidence demonstrates that cancer stem cells (CSCs) are able to cause tumor initiation, metastasis and responsible for chemotherapy and radiotherapy failures. As CSCs are though
Publikováno v:
Experimental Cell Research. 335:187-196
Epithelial-mesenchymal transition (EMT) acts as a facilitator of metastatic dissemination in the invasive margin of malignant tumors where active tumor-stromal crosstalks take place. Co-cultures of cancer cells with cancer-associated fibroblasts (CAF
Autor:
Liliana Alvarado-Ruíz, Bladimiro Rincon-Orozco, Adriana Aguilar-Lemarroy, Patricio Gariglio, Ivan D. Meza‐Canales, Frank Rösl, Luis A Torres-Reyes, Mariel García-Chagollán, Moisés Ramos-Solano, Luis Felipe Jave-Suárez, Alejandra Berenice Ochoa-Hernández, Monserrat Alvarez-Zavala, Pablo C Ortiz-Lazareno
Publikováno v:
Experimental Cell Research. 335:39-50
According to the multifactorial model of cervical cancer (CC) causation, it is now recognized that other modifications, in addition to Human papillomavirus (HPV) infection, are necessary for the development of this neoplasia. Among these, it has been
Autor:
Astrid Enkelmann, Susanne Grimm, Kerstin Junker, Nora Rippaus, Alexander Berndt, Susanne Jennek, Karlheinz Friedrich, Rajan Singh
Publikováno v:
Experimental Cell Research. 335:1-11
The microenvironment of tumor cells is critically involved in tumor development and progression. Tumor-associated fibroblasts (TAFs) represent a major constituent of the tumor stroma. Tumor cells are operative in the activation of TAFs, whereas TAFs