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Publikováno v:
Experimental Cell Research. 381:201-207
Metastasis remains the primary cause of cancer mortality. Throughout the process of metastasis, cancer cells experience mechanical forces, which may turn out to be the key towards their migratory, homeostatic and survival characteristics. However, th
Publikováno v:
Experimental Cell Research. 380:36-46
Pulmonary arterial hypertension (PAH) is a diffuse pulmonary microvascular remodeling disease accompanied by malignant proliferation of pulmonary artery smooth muscle cells (PASMCs), which causes persistent pulmonary artery pressure elevation, right
Publikováno v:
Experimental Cell Research. 380:29-35
The removal of introns from mRNA precursors (pre-mRNAs) is an essential step in eukaryotic gene expression. The splicing machinery heavily contributes to biological complexity and especially to the ability of cells to adapt to altered cellular condit
Autor:
Wenxiang Ji, Yongfeng Yu, Weiliang Xia, Ziming Li, Shan He, Yirui Cheng, Shun Lu, Qingyu Zeng
Publikováno v:
Experimental Cell Research. 379:203-213
Tumor-derived exosomes contain informative microRNAs involved in carcinogenesis, cell migration, invasion and epithelial-mesenchymal transition (EMT), eventually contributing to metastasis of cancers. This study aims to clarify which and how exosomal
Publikováno v:
Experimental Cell Research. 379:182-190
Lysine demethylase 5B (KDM5B) is up-regulated in many cancers, including breast cancer. However, the underlying metabolic mechanisms of KDM5B on breast cancer progression are poorly understood. Here, we showed that KDM5B expression positively correla
Publikováno v:
Experimental Cell Research. 378:139-148
The objective of this study was to investigate the functional role of Rab39a in human cervical cancer (CC) and the underlying molecular mechanisms. We first measured Rab39a mRNA expression in CC tissues and paired non-tumor tissues by quantitative re
Publikováno v:
Experimental Cell Research. 376:1-10
Glucoside xylosyltransferase2 (GXYLT2), a member of the human α-1,3- D -xylosyltransferases, functions to modify the first xylose to the O-Glucose residue on epidermal growth factor (EGF) repeats of Notch receptors. It is well-established that the N
Autor:
Zhengshuai Song, Xuanyu Chen, Junwei Tong, Hailong Ruan, Hongmei Yang, Qi Cao, Keshan Wang, Lin Bao, Xiaoping Zhang, Di Liu, Gong Cheng, Ke Chen, Tianbo Xu
Publikováno v:
Experimental Cell Research. 376:181-191
Renal cell carcinomas are a group of most common renal malignancies whose clinical intervention is complicated by the lack of early diagnosis and reliable prognosis biomarkers, insensitive radiotherapy and chemotherapy and expensive molecular-targete
Publikováno v:
Experimental Cell Research. 375:82-89
Endothelial-to-mesenchymal transition (EndMT) plays a pivotal role in the development of organ fibrosis and can be induced by TGF-β. It is characterized by the loss of endothelial cell markers and the acquisition of mesenchymal markers. In this stud
Autor:
Xionggen Li, Shiliang Chen, Jianxiang Chen, Shuan Liu, Weifu Wang, Dinglan Wu, Fei Wang, Qinghui Wu, Fengrong He, Housheng Fu
Publikováno v:
Experimental Cell Research. 375:1-10
Long non-coding RNA HOXA-AS2 (HOXA cluster antisense RNA 2) has been reported to function as an oncogene in different types of cancers including breast cancer, liver cancer, gastric cancer and colorectal cancer, etc. However, its role in the developm