Zobrazeno 1 - 10
of 78
pro vyhledávání: ''
Publikováno v:
Experimental and Therapeutic Medicine
Doxorubicin (DOX) has been widely employed to treat cancer, particularly solid tumors and hematological malignancies, owing to its high efficacy; however, chemotherapy has been indicated to be cardiotoxic and induce adverse effects, including mitocho
Publikováno v:
Experimental and Therapeutic Medicine
Ovarian cancer (OC) is one of the prominent causes of mortality in female patients diagnosed with gynecologic malignancies. While it has previously been demonstrated that apigenin inhibits cell growth in colon and breast cancer cells, the effect of a
Publikováno v:
Experimental and Therapeutic Medicine
Chemoresistance of colorectal cancer (CRC) leads to tumor recurrence and metastasis and new strategies are urgently needed to improve the outcomes of conventional chemotherapy. Sirtuin (SIRT) inhibitors prevent tumor cell growth by increasing the lev
Autor:
Yu Jiang, Shulin Huang, Mengchuan Wang, Aiguo Wu, Zili He, Peizhi Fan, Chaojie Zhang, Meng Fang, Shanshan Lei
Publikováno v:
Experimental and Therapeutic Medicine
Based on its pathological characteristics, breast cancer is a highly heterogeneous disease. Triple negative breast cancer (TNBC) is an aggressive subtype, and due to a lack of effective therapeutic targets, patients with TNBC do not significantly ben
Publikováno v:
Experimental and Therapeutic Medicine
Cervical cancer is the most lethal malignancy amongst women worldwide. MicroRNAs (miRNAs/miRs) play a critical role in the progression of cervical cancer. Compelling evidence indicates that miR-584 acts as a tumor suppressor in some types of cancers.
Publikováno v:
Experimental and Therapeutic Medicine
The present study aimed to investigate the regulatory mechanisms by which interleukin (IL)-22 regulates cisplatin (DDP) sensitivity in osteosarcoma cells. Firstly, reverse transcription-quantitative (RT-q) PCR and western blotting demonstrated that I
Publikováno v:
Experimental and Therapeutic Medicine
MicroRNA-138 (miR-138) acts as a key regulator in the modulation of carcinogenesis in numerous tumor types. Chemoresistance is common and relevant to the failure of multiple treatment strategies for cervical cancer. However, the biological role of mi
Autor:
Daniela Miricescu, Guenadiy Vatachki, Ileana Adela Vacaroiu, Constantin Ştefani, Raluca Papacocea, Mihaly Enyedi, Daniela Gabriela Balan, Dragoș Eugen Georgescu, Doina Andrada Mihai, Ovidiu Stiru, Nedelea Andrei Sorin, Cristian Constantin Popa, Adrian Tulin, Adriana Elena Nica
Publikováno v:
Experimental and Therapeutic Medicine
Renal cell carcinoma (RCC) accounts for over 90% of all renal malignancies, and mainly affects the male population. Obesity and smoking are involved in the pathogenesis of several systemic cancers including RCC. The phosphoinositide 3-kinase (PI3K)/p
Publikováno v:
Experimental and Therapeutic Medicine
Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) are two types of head and neck cancers with high incidence rates and relatively poor prognoses. The aim of the present study was to determine the effects of m
Publikováno v:
Experimental and Therapeutic Medicine
Fibroblast growth factor receptor 3 (FGFR3) is a high frequency mutant gene in bladder cancer (BCa) and has become a promising therapeutic target due to its involvement in cell proliferation and migration. However, whether and how FGFR3 mutations aff