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Autor:
M. N. Ahmad, Norhasimah Bakar, Alan Soo-Beng Khoo, Maelinda Daker, Tiong-Chia Yeo, Jiun-Tzen Yeo, Asma' Saiyidatina Aishah Abdul Abdul Rahman
Publikováno v:
Experimental and Therapeutic Medicine. 11:2117-2126
Nasopharyngeal carcinoma (NPC) is a type of tumour that arises from the epithelial cells that line the surface of the nasopharynx. NPC is treated with radiotherapy and cytotoxic chemotherapeutic drugs such as cisplatin and 5-fluorouracil. However, cu
Autor:
Zhen‑Yuan Gao, Ming‑Hong Bi, Zhe Liu, Zheng‑Quan Han, Xiao Han, Hao Liu, Guo‑Ping Sun, Hong‑Ya Wang, Jing-Jing Zhang
Publikováno v:
Experimental and Therapeutic Medicine
Breast cancer is the most commonly occurring cancer and second leading cause of mortality in women. Metformin is a widely prescribed anti-hyperglycemic drug, which is emerging as a potential cancer preventative and treatment agent. However, the mecha
Publikováno v:
Experimental and Therapeutic Medicine
Upon peripheral nerve injury (PNI), continuous proliferation of Schwann cells is critical for axon regeneration and tubular reconstruction for nerve regeneration. Melatonin is a hormone that is able to induce proliferation in various cell types. In t
Publikováno v:
Experimental and Therapeutic Medicine
Breast cancer is the most common cancer in women worldwide, and the incidence and mortality rates are increasing every year. Dysregulation of microRNAs (miRNAs or miRs) is an important step in the initiation and development of breast cancer. Previous
Autor:
Fengchang Qiao, Pihai Gong, Zhujiang Zhao, Ying Zheng, Hong Fan, Yuhang Mao, Yuejun Gu, Xiaohui Shen, Shengling Yu, Yiping Li
Publikováno v:
Experimental and Therapeutic Medicine
Resistance to chemotherapeutic drugs leads to a poor prognosis in gastric cancer (GC). The present study aimed to assess the association between pituitary homeobox paired homeodomain transcription 1 (PITX1) expression and the sensitivity of GC cells
Publikováno v:
Experimental and Therapeutic Medicine
The present study evaluated the effect of metformin on the SKOV3 ovarian cancer cell line and investigated the underlying mechanism. The inhibitory rate of SKOV3 cells was analyzed by MTT assay. SKOV3 cell apoptosis rate was quantitatively measured u
Publikováno v:
Experimental and Therapeutic Medicine
Ovarian cancer is the leading cause of mortality resulting from gynecologic cancer. A common anti-ovarian tumor drug is cisplatin; however, repeated use of cisplatin causes severe resistance and leads to poor long-term survival rate in ovarian cancer
Publikováno v:
Experimental and therapeutic medicine. 19(1)
The limited efficacy of chemotherapy with Taxol (TAX) and cisplatin (DDP) in triple-negative breast cancer (TNBC) has prompted the investigation of combined therapies. Previous studies demonstrated that microRNA (miR)-31-5p is involved in various bio
Publikováno v:
Experimental and therapeutic medicine. 17(1)
The aim of the current study was to assess the underlying mechanism of endoplasmic reticulum protein 29 (ERp29) in lung adenocarcinoma chemosensitivity to gemcitabine. Western blot analysis was performed to detect ERp29 expression following lung aden
Publikováno v:
Experimental and Therapeutic Medicine.
The incidence of congenital hypothyroidism (CH) in newborn infants ranges from 1 in 3,000 to 1 in 4,000. Previous studies have indicated the neuroprotective role of microRNA (miR)-124-3p, however the expression and role of miR-124-3p in CH remain unc