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Publikováno v:
Experimental and Therapeutic Medicine
Nasopharyngeal carcinoma (NPC) is one of the most common malignant head and neck cancers in southern China. Although the local and regional control of NPC has been considerably improved, patients with advanced disease still suffer from poor prognosis
Autor:
Chao-Qun Huang, Xiao-Jun Yang, Jiuyang Liu, Xuekai Pan, Bin Xiong, Maohui Feng, Chun-Wei Peng
Publikováno v:
Experimental and Therapeutic Medicine
MicroRNA-454 (miR-454), is involved in the progression of various types of cancers. The present study aimed to evaluate the effect of miR-454 on the progression of gastric cancer. SGC-7901 cells overexpressing or silencing miR454 were constructed via
Publikováno v:
Experimental and Therapeutic Medicine
Effective chemotherapeutic strategies for uterine sarcoma are lacking; existing therapies achieve poor response rates. Previous studies have identified the prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) as a potential anticancer treatment
Publikováno v:
Experimental and Therapeutic Medicine
Gastric cancer is the fifth most common malignancy and the third highest cause of cancer-associated mortality worldwide. Therefore, research on the pathogenesis of gastric cancer is of utmost importance. It has been reported that aberrant activation
Autor:
Zhen‑Yuan Gao, Ming‑Hong Bi, Zhe Liu, Zheng‑Quan Han, Xiao Han, Hao Liu, Guo‑Ping Sun, Hong‑Ya Wang, Jing-Jing Zhang
Publikováno v:
Experimental and Therapeutic Medicine
Breast cancer is the most commonly occurring cancer and second leading cause of mortality in women. Metformin is a widely prescribed anti-hyperglycemic drug, which is emerging as a potential cancer preventative and treatment agent. However, the mecha
Autor:
Fengchang Qiao, Pihai Gong, Zhujiang Zhao, Ying Zheng, Hong Fan, Yuhang Mao, Yuejun Gu, Xiaohui Shen, Shengling Yu, Yiping Li
Publikováno v:
Experimental and Therapeutic Medicine
Resistance to chemotherapeutic drugs leads to a poor prognosis in gastric cancer (GC). The present study aimed to assess the association between pituitary homeobox paired homeodomain transcription 1 (PITX1) expression and the sensitivity of GC cells
Publikováno v:
Experimental and Therapeutic Medicine
Ovarian cancer is the leading cause of mortality resulting from gynecologic cancer. A common anti-ovarian tumor drug is cisplatin; however, repeated use of cisplatin causes severe resistance and leads to poor long-term survival rate in ovarian cancer
Autor:
Hai‑Ying Gao, Wan‑Peng Wang
Publikováno v:
Experimental and Therapeutic Medicine
Avoidance of apoptosis induced by anticancer drugs is an essential factor of carcinogenesis and a hallmark of resistance to cancer therapy. Human telomerase reverse transcriptase receptor (hTERTR) is a potential anti-cancer agent for inhibiting tumor
Publikováno v:
Experimental and therapeutic medicine. 15(1)
Chemotherapy is an important treatment modality for gastric cancer, and multidrug resistance (MDR) represents a major obstacle for successful cancer chemotherapy. There is a lack of research on whether microRNA (miR)-30a regulation affects the chemos
Publikováno v:
Experimental and therapeutic medicine. 11(2)
Resistance to chemotherapy is a major challenge in the effective treatment of patients with gastric cancer; however, the mechanisms underlying chemoresistance in gastric cancer cells are yet to be elucidated. MicroRNAs (miRNAs) have previously been a