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Autor:
Yu Sun Jeong, Yoe-Sik Bae
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1694-1704 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor (GPCR) family and are well known as chemotactic receptors and pattern recognition receptors (PRRs) that recognize bacterial and mitochondria-derived formylated peptides. FPRs ar
Autor:
Zhipeng Meng, Minmin Zhu, Huanzhong He, Xuefang Shen, Qichao Wu, Yuqin Hu, Qing Hua, Jing Liu, Jing Wang, Xiangyuan Chen, Yanguang Su, Wanxia Xiong, Zhiyao Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1715-1729 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 partic
Autor:
Hansoo Park, Sungsoon Fang, Mongjoo Jang, Jeong Hyeon Park, Youngmin Yoon, Gihyeon Kim, Myung-Giun Noh
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1574-1586 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which L
Autor:
Jin-Kwan Lee, Si-Yeon Lee, Suhyeon Kim, Kyungrim Hwang, Heounjeong Go, Chang-Woo Lee, Seoyoon Bae
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1537-1549 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established pso
Autor:
Jong Gil Park, Sinai Kim, Sang Hak Lee, Goo Taeg Oh, In Hyuk Jung, Na Young Ko, Se Jin Jeong, Jeong Ki Min, Min Ji Cho
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1587-1601 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1255-1263 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
T cells are the central mediators of both humoral and cellular adaptive immune responses. Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen-specific immunity. In addition, encounters with cognate antigens gene
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1039-1047 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The roles of the two isoforms of ErbB3-binding protein 1 (Ebp1) in cellular function and its regulation in disease and development is a stimulating area in current fields of biology, such as neuroscience, cancer biology, and structural biology. Over
Autor:
Thi Bich Tra Cao, Quoc Quang Luu, Seung-Hyun Kim, Thuy Van Thao Nguyen, Seo-Hee Kim, Hae-Sim Park, Hoang Kim Tu Trinh
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 2, Pp 253-265 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Patients with late-onset asthma (LOA) have poor clinical outcomes. Osteopontin (OPN) is associated with airway inflammation and remodeling. To investigate the role of OPN in LOA compared to early-onset asthma (EOA), serum OPN levels were compared bet
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-13 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive i
Autor:
Jeong Hun Kim, Jongjin Park, Hyejin Jang, Sang-Hyun Lee, Young Lai Cho, Young-Jun Park, Jeong Ki Min, Min Ji Cho, Jong Gil Park, Sung Jin Yoon, Jangwook Lee, Wooil Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 10, Pp 1-13 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The disruption of the retinal pigment epithelium (RPE), for example, through oxidative damage, is a common factor underlying age-related macular degeneration (AMD). Aberrant autophagy also contributes to AMD pathology, as autophagy maintains RPE home