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Autor:
Dong Hyun Kim, Eun Ji Song, Moonkyung Kang, Yeon-Soo Kim, Inhee Mook-Jung, Dong Woo Nam, Minho Moon, Seong Gak Jeon
Publikováno v:
Experimental & Molecular Medicine
Progressive cognitive declines are the main clinical symptoms of Alzheimer’s disease (AD). Cognitive impairment in AD is directly correlated with amyloid beta (Aβ)-mediated synaptic deficits. It is known that upregulation of neurogranin (Ng), a po
Autor:
Tineke E. Buffart, Dennis Poel, Jolanda E. W. Oosterling-Jansen, Jens Voortman, Henk M.W. Verheul
Publikováno v:
Experimental & Molecular Medicine
Poel, D, Buffart, T E, Oosterling-Jansen, J, Verheul, H M & Voortman, J 2018, ' Evaluation of several methodological challenges in circulating miRNA qPCR studies in patients with head and neck cancer ', Experimental & Molecular Medicine, vol. 50, no. 3, pp. e454 . https://doi.org/10.1038/emm.2017.288
Experimental & Molecular Medicine, 50(3). Korean Society of Med. Biochemistry and Mol. Biology
Poel, D, Buffart, T E, Oosterling-Jansen, J, Verheul, H M & Voortman, J 2018, ' Evaluation of several methodological challenges in circulating miRNA qPCR studies in patients with head and neck cancer ', Experimental & Molecular Medicine, vol. 50, no. 3, pp. e454 . https://doi.org/10.1038/emm.2017.288
Experimental & Molecular Medicine, 50(3). Korean Society of Med. Biochemistry and Mol. Biology
Circulating microRNAs (ci-miRNAs) in blood have emerged as promising diagnostic, prognostic and predictive biomarkers in cancer. Many clinical studies currently incorporate studies that assess ci-miRNAs. Validation of the clinical significance of can
Publikováno v:
Experimental & Molecular Medicine
Phosphatidylinositol 3-kinase (PI3K) signaling plays an important role in the regulation of cellular lipid metabolism and non-alcoholic fatty liver disease (NAFLD). However, little is known about the role of the regulatory subunits of PI3K in lipid m
Autor:
Ting-Chia Chiu, Po-Han Chen, Ming-Shian Tsai, Yu-Chun Lin, Po-Huang Lee, I-Wei Chang, Cheuk-Kwan Sun, Ying-Hsien Kao
Publikováno v:
Experimental & Molecular Medicine
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF t
Autor:
Karsten Müssig, Iris Ziegler, Alexander Strom, Dan Ziegler, Michael Roden, Kirti Kaul, Ilka Rokitta, Julia Szendroedi, Jutta Brüggemann, Sonja Püttgen
Publikováno v:
Experimental & Molecular Medicine
Experimental & molecular medicine, 49:e394
Experimental & molecular medicine, 49:e394
Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with di
Autor:
Peng Chen, Zhenguo Chen, Jing Nie, Yong Jiang, Tian Lan, Jun-Qi Lu, Zhi Xiong, Jieyan Wang, Shan Wu, Guizhi Yang, Wenli Tang, Hongwei Zhou, Haihua Luo, Jingjuan Hu
Publikováno v:
Experimental & Molecular Medicine
Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated how high salt (HS) intake triggers early
Autor:
Qinghua Wang, Limei Li, Yong-quan Shi, Liang-liang Sun, Tian-Jin Liu, Jin Cen, Xiaotao Chen, Lijian Hui, Zhaoyun Zhang, Xin Cheng, Bei-Ge Jiang
Publikováno v:
Experimental & Molecular Medicine
α-cells, which synthesize glucagon, also support β-cell survival and have the capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological conditions and their putative clinical applications remain elusive due in larg
Autor:
Zi-Jiang Chen, Yafang Sun, Yueran Zhao, Yulian Jiao, Laicheng Wang, Yinchang Wang, Muyun Wei, Bin Cui, Bingru Lu, Jing Dong, Bingchang Zhang
Publikováno v:
Experimental & Molecular Medicine
Paget's disease of bone (PDB) is a common metabolic bone disease that is characterized by aberrant focal bone remodeling, which is caused by excessive osteoclastic bone resorption followed by disorganized osteoblastic bone formation. Genetic factors
Publikováno v:
Experimental & Molecular Medicine
We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to esta
Publikováno v:
Experimental & Molecular Medicine
To explore the association of serum Dickkopf-1 (DKK-1) levels with the development of ankylosing spondylitis (AS) and rheumatic arthritis (RA) in humans, databases including PubMed, EBSCO, Springerlink, Ovid, WANFANG and China National Knowledge Infr