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Autor:
Bernard Masereel, Jacques Delarge, Marra Ferrandi, Bernard Pirotte, Marc Schynts, Paolo Parenti, Patrizia Ferrari
Publikováno v:
European Journal of Pharmacology. 219:385-394
A series of compounds related to torasemide, a loop diuretic, were synthesized and examined for their diuretic potency and inhibitory activity on the erythrocyte and renal medullary thick ascending limb vesicle Na+,2Cl-,K+ cotransport in Milan hypert
Publikováno v:
European Journal of Pharmacology. 219:135-140
The action of a novel 5-HT 3 receptor antagonist, AS-5370, has been studied on two electrophysiological models for 5-HT 3 receptors: whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma (NG108-15) cells and grease-gap recordings from
Autor:
Angela Williams, Colin T. Dourish
Publikováno v:
European Journal of Pharmacology. 219:105-112
The effects of the putative 5-HT 1A receptor antagonist NAN-190 on feeding and spontaneous locomotor activity in rats were examined. The drug elicited a robust, dose-dependent (0.01–;10 mg/kg) increase in food consumption in free feeding animals. M
Publikováno v:
European Journal of Pharmacology. 218:229-236
The 5-HT 3 receptor antagonists zacopride and GR38032F are highly effective inhibitors of emesis induced by ionizing radiation and chemotherapeutic drugs such as cisplatin. The present study evaluated zacopride and GR38032F for efficacy in inhibiting
Autor:
Maria D. Barrachina, Brendan J.R. Whittle, M. A. Martínez-Cuesta, Juan V. Esplugues, J.M. Piqué
Publikováno v:
European Journal of Pharmacology. 218:351-354
Administration of E. coli endotoxin (1 mg/kg i.v.) abolished the acid secretory response induced by a bolus injection of pentagastrin (100 micrograms/kg i.v.) in the continuously perfused stomach of the anaesthetized rat. Endotoxin administration did
Publikováno v:
European Journal of Pharmacology. 218:159-169
The discriminative cues induced by the muscarinic receptor agonists Lu 26-046 ((-)-7-methyl-3(2-propynyloxy)-4,5,6,7-tetrahydroisothiazolo [4,5-c]pyridine ) and O-Me-THPO (3-methoxy-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine) were investigated. The r
Publikováno v:
European Journal of Pharmacology. 216:47-52
Changes in mechanical events and intracellular levels of cAMP induced by the activation of the 5-HT4 receptor were investigated in the rat esophagus tunica muscularis mucosae preparation. Serotonin (5-HT) and 5 methoxytryptamine (5-MOT; 5-HT4 agonist
Autor:
Maurizio Memo, M. O. Carruba, Giuseppe Reina, Marina Pizzi, Cristina Tonello, PierFranco Spano, E. Nisoli
Publikováno v:
European Journal of Pharmacology. 216:81-86
We studied the adaptive changes of the locomotor effects of lisuride, a selective agonist for dopamine (DA) D 2 receptors, and the functional state of D 1 and D 2 receptors after repeated administration of lisuride at a dose supposed to act preferent
Publikováno v:
European Journal of Pharmacology. 215:23-28
To study the mechanism by which bombesin induces satiety, we studied the effect of two new peptides, BIM187, a bombesin agonist, and BIM189, a bombesin antagonist, on food intake in rats fed 6 h a day. BIM187 at 4 μg/kg, significantly reduced food i
Autor:
Naoto Yamada, Mathew T. Martin-Iverson
Publikováno v:
European Journal of Pharmacology. 215:119-125
The effects of continuous subcutaneous infusions of rats for 336 h with vehicle, SKF 38393 (a dopamine D1 receptor agonist), (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, a dopamine D2 receptor agonist) or both D1 and D2 receptor agonists, on locomotor