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Autor:
Bao-Yan Wu, Ying-Jie Shang, Zhong-Si-Wei Dong, Zhi-Ping Cao, Wen-Xiao Liu, Qi-Yao Liu, Chu-Hua Li
Publikováno v:
European Journal of Pharmacology. 853:325-335
Cerebral ischemia impairs physiological form of synaptic plasticity such as long-term potentiation (LTP). Clinical symptoms of cognitive dysfunction resulting from cerebral ischemia are associated with neuron loss and synaptic function impairment in
Publikováno v:
European Journal of Pharmacology. 848:88-95
In the brain, various neurotransmitters such as noradrenaline and GABA regulate peripheral sympathetic functions. Previously, it has been reported that both β-adrenoceptor activation and GABAB receptor activation in the brain are involved in the ele
Publikováno v:
European journal of pharmacology. 899
The recently identified molecule P7C3 has been highlighted in the field of pain research. We examined the effect of intrathecal P7C3 in tissue injury pain evoked by formalin injection and determined the role of the GABA system in the activity of P7C3
Autor:
Gongliang Zhang, Gregory V. Carr, Spencer Byers, Michael DePasquale, Gangling Liao, Ingrid P. Buchler, Yupin Su, Huijun Wei, James C. Barrow
Publikováno v:
Eur J Pharmacol
Impaired dopamine activity in the dorsolateral prefrontal cortex (DLPFC) is thought to contribute to cognitive deficits in diseases such as schizophrenia, attention deficit hyperactivity disorder (ADHD) and traumatic brain injury. Catechol-O-methyltr
Autor:
Asami Mori, Taiyo Kuroki, Hiroko Ito, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii, Tomonori Sagawa
Publikováno v:
European Journal of Pharmacology. 812:57-63
Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo. It has been reported that morphine, an
Autor:
Sara Marchesan Oliveira, Allisson Benatti Justino, Rahisa Scussel, Cássia Regina Silva, Indiara Brusco, Ricardo Andrez Machado-de-Ávila
Publikováno v:
European Journal of Pharmacology. 895:173870
Fibromyalgia is a potentially disabling chronic disease, characterized by widespread pain and a range of comorbidities such as hypertension. Among the mechanisms involved in fibromyalgia-like pain symptoms are kinins and their B1 and B2 receptors. Mo
Publikováno v:
European Journal of Pharmacology. 806:83-90
Anxiolytics and anticonvulsants generally positively modulate the action of GABA, whereas many convulsants (including the chloride channel blocker picrotoxinin) negatively modulate the action of GABA on GABAA receptors. Like picrotoxinin, bilobalide
Autor:
Maria Paula Serrão, Fernanda Borges, Patrício Soares-da-Silva, Tiago H. Silva, Sofia Pinheiro
Publikováno v:
European journal of pharmacology. 847
Currently, peripheral COMT inhibitors have an important role in the treatment of Parkinson's disease, and central COMT inhibitors have a potential role in the treatment of various neuropsychiatric disorders, such as attention deficit hyperactivity di
Publikováno v:
European Journal of Pharmacology. 884:173437
The GABA analog phenibut (β-Phenyl-GABA) is a GABAB receptor agonist that has been licensed for various uses in Russia. Phenibut is also available as a dietary supplement from online vendors worldwide, and previous studies have indicated that phenib
Publikováno v:
European Journal of Pharmacology. 781:45-52
Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effec