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Publikováno v:
European journal of pharmacology. 464(1)
Cocaine- and amphetamine-regulated transcript (CART) peptide (CART-(55–102)) is involved in the suppression of food intake. We now report that CART-(55–102) is involved in anxiety in rodents. Intracerebroventricularly administered CART-(55–102)
Publikováno v:
European journal of pharmacology. 454(2-3)
We investigated the effects of neuroactive steroids on N-methyl-D-aspartate (NMDA) cytotoxicity in cultured rat cortical neurons. 3alpha-hydroxy-5beta-pregnan-20-one sulfate (3alpha5betaS) attenuated, whereas pregnenolone sulfate and pregnenolone hem
Autor:
René Drucker-Colín, Stefan Mihailescu, Marı́a del Carmen Frı́as Domı́nguez, Ruben Guzman-Marin
Publikováno v:
European journal of pharmacology. 452(1)
Nicotine, locally administered into the dorsal raphe nucleus (DRN) of rat midbrain slices, increased the discharge rate of 70% of serotoninergic neurons, decreased it in 30% and induced reciprocal oscillatory increases in serotonin (5-hydroxytryptami
Publikováno v:
European journal of pharmacology. 452(1)
Staurosporine-induced apoptosis was associated with a 20% cellular survival rate in primary rat forebrain cultures. Treatment with the NR2B subunit-selective NMDA receptor antagonist conantokin-G (0.1-1 microM) increased the survival rate up to 78%.
Autor:
Keith B.J. Franklin, Annie-Kim Gilbert
Publikováno v:
European journal of pharmacology. 449(1-2)
There has been controversy as to whether the contribution of descending fibers from the rostral ventromedial medulla to opioid analgesia depends on the nature of the noxious stimulus eliciting pain. In the present study, inactivation of descending fi
Autor:
Melanie Hamann, Angelika Richter
Publikováno v:
European journal of pharmacology. 443(1-3)
The underlying mechanisms of idiopathic dystonias are poorly understood. The dystonic phenotype in the dt(sz) mutant hamster, a model of paroxysmal dystonia, has been suggested to be based on a deficit of gamma-aminobutyric acid (GABA)ergic interneur
Publikováno v:
European journal of pharmacology. 438(1-2)
We examined the effects of gamma-aminobutyric acid (GABA) on the blood pressure in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. A single oral administration (0.5 mg/kg) significantly lowered the systolic blood pressure in spont
Publikováno v:
European journal of pharmacology. 431(2)
Our recent study demonstrated that neurosteroids might either facilitate or block chronic tolerance to the incoordinating effects of ethanol. The present study investigated the effects of neurosteroids on the development of rapid tolerance to ethanol
Publikováno v:
European journal of pharmacology. 430(2-3)
The effect of gamma-hydroxybutyric acid (GHB) and baclofen, a GABA(B) receptor agonist, on extracellular hippocampal acetylcholine levels was studied in freely moving rats by microdialysis. GHB (200 and 500 mg/kg, i.p.) reduced in a dose-dependent ma
Autor:
Chiara Di Nisio, Giustino Orlando, Barbara Michelotto, Luigi Brunetti, Giovanni Ciabattoni, Lucia Recinella, Michele Vacca
Publikováno v:
European journal of pharmacology. 430(2-3)
We have studied the effects of cocaine- and amphetamine-regulated transcript (CART) peptide-(55–102), leptin, orexin-A and orexin-B on basal and depolarization (K + 15 mM)-induced serotonin (5-hydroxytryptamine, 5-HT) release from rat hypothalamic