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Publikováno v:
European Journal of Pharmacology. 389:147-153
5-Hydroxytryptamine(1A) (5-HT(1A)) receptors, which activate inhibitory G-proteins, are implicated in psychiatric disorders including anxiety and depression. Studies suggest that chronic 5-HT(1A) receptor agonist administration alters 5-HT(1A) recept
Autor:
Seiichiro Shimazu, Akinori Akaike, Chikako Takenaka, Toshiaki Kume, Shuji Kaneko, Michiko Tomita, Hiroshi Katsuki
Publikováno v:
European Journal of Pharmacology. 388:139-146
We investigated the potential neuroprotective effects of several sigma receptor ligands in organotypic midbrain slice cultures as an excitotoxicity model system. When challenged with 100-microM N-methyl-D-aspartate (NMDA) for 24 h, dopaminergic neuro
Publikováno v:
European Journal of Pharmacology, 279-286. ELSEVIER SCIENCE BV
STARTPAGE=279;ENDPAGE=286;ISSN=0014-2999;TITLE=European Journal of Pharmacology
European Journal of Pharmacology, 387(3), 279-286. ELSEVIER SCIENCE BV
STARTPAGE=279;ENDPAGE=286;ISSN=0014-2999;TITLE=European Journal of Pharmacology
European Journal of Pharmacology, 387(3), 279-286. ELSEVIER SCIENCE BV
This study was aimed to identify the neuronal pathways that mediate the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex of the rat brain. For that purpose a microdialysis probe was implanted in the vic
Autor:
Amotz Nechushtan, Le-Ping He, Graeme Eisenhofer, Eduardo Rojas, Rusnak Milan, Itschak Lamensdorf, Judith Harvey-White, Irwin J. Kopin
Publikováno v:
European Journal of Pharmacology. 388:147-154
Sulfonylureas block ATP-dependent K(+) channels (K/ATP channels) in pancreatic beta cells and brain gamma-aminobutyric acid (GABA) containing neurons causing depolarization-evoked insulin or GABA release. In high concentrations, sulfonylureas also in
Publikováno v:
European Journal of Pharmacology. 382:139-142
High-affinity, Na(+)-dependent transport of glutamate into neurons and glial cells maintains the extracellular concentration of this neurotransmitter at a sub-toxic level. Chronic blockade of dopamine D(2) receptors with haloperidol elevates extracel
Publikováno v:
European Journal of Pharmacology. 378:259-263
The density of dopamine D 1 receptor antagonist sites was measured by autoradiography and dopamine D 1 receptor mRNA levels were measured by in situ hybridization in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed monkeys
Publikováno v:
European Journal of Pharmacology. 376:149-157
Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-aminobutyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an
Autor:
Soichiro Ide, Kyoko Sakano, Takahiro Seki, Chiaki Kimura, Hiroshi Nagase, Masamichi Satoh, Shinichiro Awamura, Masabumi Minami
Publikováno v:
European Journal of Pharmacology. 376:159-167
We analyzed the pharmacological properties of 17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6b eta-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride (TRK-820) using Chinese hamster ovary (CHO) cells expressing cloned rat mu-, del
Publikováno v:
European Journal of Pharmacology. 377:29-34
The potential neuroprotective effect of (−)-deprenyl (R-N,α-dimethyl-N-2-propynylbenzeneethanamine) against N-methyl- d -aspartate (NMDA) excitotoxicity was investigated on rat mesencephalic dopaminergic neurons in organotypic slice cultures. Whil
Publikováno v:
European Journal of Pharmacology. 367:207-211
Cholinergic twitch responses in the guinea-pig isolated ileum, and spontaneous discharges in rat neocortical slices, were depressed by the GABA(B) receptor agonist baclofen. These actions were reversibly antagonised by the sulphonamide derivatives (R