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Autor:
Leosvaldo S. M. Velozo, Juliana M Raimundo, Maria Auxiliadora Coelho Kaplan, Gisele Zapata-Sudo, Ana Paula Felix Trindade, Roberto T. Sudo
Publikováno v:
European Journal of Pharmacology. 606:150-154
In Brazilian folk medicine, extracts from Piper species are used to reduce blood pressure. Previously, we demonstrated the vasodilatory activity of crude extracts from leaves of Piper truncatum explaining their possible use in the treatment of hypert
Autor:
Carlos R. Tirapelli, Ana Maria de Oliveira, Fernando B. Da Costa, Silvia T Coutinho, Dionéia Camilo Rodrigues de Oliveira, Sérgio Ricardo Ambrósio
Publikováno v:
European Journal of Pharmacology. 492:233-241
The present work describes the mechanisms involved in the vasorelaxant effect of the diterpene ent-kaur-16-en-19-oic acid (kaurenoic acid). Kaurenoic acid (10, 50 and 100 microM) concentration-dependently inhibited phenylephrine and KCl-induced contr
Publikováno v:
European Journal of Pharmacology. 458:183-189
The aim of present study was to characterize the in vitro and in vivo pharmacological effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a soluble guanylate cyclase activator, on corpus cavernosal smooth muscle and penile erectile act
Autor:
Hiromasa Inoue, Hisamichi Aizawa, Satoru Fukuyama, Nobuyuki Hara, Sankei Nishima, Naotsugu Takahashi
Publikováno v:
European Journal of Pharmacology. 410:61-68
A non-phorbol ester-type tumor promoter, thapsigargin has been reported to deplete Ca(2+) stores in endothelial cells by inhibiting Ca(2+)-ATPase, which in turn increases intracellular Ca(2+) by mobilization of extracellular Ca(2+), leading to activa
Publikováno v:
European Journal of Pharmacology. 397:169-176
We propose that ATP-sensitive K(+) (K(ATP)) channels are normally inactive but involved in beta(2)-adrenoceptor stimulated relaxation of the rat bladder. Spontaneous detrusor muscle contractions were unaffected by glibenclamide (K(ATP) channel blocke
Publikováno v:
European Journal of Pharmacology. 385:191-197
The effects of pranidipine, a novel dihydropyridine-type Ca 2+ -channel antagonist, on acetylcholine-induced endothelium-dependent relaxation were investigated in isolated carotid artery of the guinea-pig. In arteries contracted with high-K + solutio
Publikováno v:
European Journal of Pharmacology. 376:325-329
In mouse anococcygeus cells, simultaneous measurements of membrane currents and changes in intracellular Ca 2+ were obtained using “perforated-patch” whole-cell recordings and Fura-2 microfluorimetry. Carbachol (50 μM) and cyclopiazonic acid (10
Publikováno v:
European Journal of Pharmacology. 362:183-192
Simultaneous recordings of membrane potential and force, and cytoplasmic calcium ([Ca2+]i) and force were made in rat anococcygeus to determine whether membrane hyperpolarisation plays a role in cyclic nucleotide-induced relaxation. In the presence o
Publikováno v:
European Journal of Pharmacology. 360:43-50
This study investigates the mechanism whereby the antioxidant 2-t-butyl-4-methoxyphenol (BHA) relaxes guinea pig gastric fundus smooth muscle. In circular smooth muscle strips, 10 microM cyclopiazonic acid, a specific inhibitor of sarcoplasmic reticu
Autor:
Hiroaki Shiokawa, Kazuyuki Nagai, Akinori Hiramoto, Masuo Ohashi, Takeo Itoh, Seigo Fujimoto, Yuusuke Inoue
Publikováno v:
European Journal of Pharmacology. 353:239-246
The effects of olprinone, a cardiotonic agent that inhibits cyclic GMP (cGMP)-inhibited phosphodiesterase, was studied on isolated rabbit mesenteric small artery and vein. In the presence of indomethacin and propranolol, olprinone at concentrations o