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Publikováno v:
European Journal of Pharmacology. 592:151-157
Prostatic A 2A adenosine receptors mediate varied effects. This study aimed to test whether genetic disruption of this receptor affects prostate contractility. Prostates taken from mice which were homozygous (A 2A R−/−) and heterozygous (A 2A R+/
Autor:
Aron Jurkiewicz, Luciana Ferreira Verde, Maria Christina W. Avellar, Neide H. Jurkiewicz, Afonso Caricati-Neto, Haydée Rezende Reuter
Publikováno v:
European Journal of Pharmacology. 543:141-150
The rat testicular capsule is a thin tissue surrounding the testis, whose precise function is still unknown. We have studied the contractile effects of electrical field stimulation, noradrenaline, and the blockade by antagonists of adrenergic recepto
Autor:
Neil C.E. Smith, Geoffrey Burnstock
Publikováno v:
European Journal of Pharmacology. 498:241-248
Mechanisms of postjunctional synergism between adenosine 5'-triphosphate (ATP) and noradrenaline were studied in isolated guinea pig vas deferens. Whereas prior exposure to ATP had no significant effect on noradrenaline-mediated contractions, noradre
Publikováno v:
European Journal of Pharmacology. 422:127-135
In this study, alpha(1)-adrenoceptor subtypes were characterised in rat femoral resistance arteries mounted on a small vessel myograph. A-61603 was found to be more potent than noradrenaline and phenylephrine in these arteries. Brimonidine (UK 14304)
Publikováno v:
European Journal of Pharmacology. 385:191-197
The effects of pranidipine, a novel dihydropyridine-type Ca 2+ -channel antagonist, on acetylcholine-induced endothelium-dependent relaxation were investigated in isolated carotid artery of the guinea-pig. In arteries contracted with high-K + solutio
Publikováno v:
European Journal of Pharmacology. 384:25-30
The alpha(1)-adrenoceptor subtype mediating noradrenaline-induced contractions of the guinea-pig isolated prostatic smooth muscle was investigated. Noradrenaline produced concentration-dependent contractions of the tissue with a mean pD(2) value of 5
Publikováno v:
European Journal of Pharmacology. 373:41-49
Pentoxifylline, a methylxanthine derivative, has been widely used to improve erythrocyte deformability and capillary blood circulation in patients with claudication and cerebrovascular disorders as well as in animals with sepsis. Here, we investigate
Autor:
André S. Pupo
Publikováno v:
European Journal of Pharmacology. 351:217-223
The effects of castration on alpha1-adrenoceptors in rat vas deferens were investigated by determining the actions of selective antagonists against the contractions induced by noradrenaline. The results obtained in vas deferens from control rats sugg
Chloroethylclonidine and α-adrenoceptor agonist interaction in blood vessels following heart failure
Autor:
Yen le Tran, Christine Forster
Publikováno v:
European Journal of Pharmacology. 336:177-185
This study examined the interaction of chloroethylclonidine with alpha-adrenoceptor agonists in canine endothelium-denuded dorsal pedal artery and saphenous vein before (non-paced) and at end-stage heart failure which was induced by rapid ventricular
Publikováno v:
European Journal of Pharmacology. 335:211-219
Capsaicin (5 x 10[-8] to 5 x 10[-5] M) produced a non-adrenergic and non-cholinergic phasic relaxation in a concentration-dependent manner in isolated dog urethral preparations precontracted by noradrenaline. The mode of action of capsaicin was inves