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Publikováno v:
European Journal of Pharmacology. 740:112-120
Hydrogen sulfide (H2S) is considered to be a signaling molecule. The precise mechanisms underlying H2S-related events, including the producing enzymes and target molecules in gastrointestinal tissues, have not been elucidated in detail. We herein exa
Autor:
Luciana Ferreira Verde, Silvia S. M. Ihara, Neide H. Jurkiewicz, Guiomar Silva Lopes, Aron Jurkiewicz
Publikováno v:
European Journal of Pharmacology. 735:211-218
Our purpose was to verify if alcohol causes alterations on translocation of Ca2+ and tension induced by KCl or noradrenaline in vas deferens of periadolescent Wistar rats. A single dose of alcohol (i.p. 3.0 g/kg) or saline as control, was given 4 h b
Autor:
Kyung Do Kim, June Hyun Han, Soon Chul Myung, Soo Hyun Park, Shin Young Lee, Moo Yeol Lee, Hae Jong Kim
Publikováno v:
European Journal of Pharmacology. 715:420-423
This study was designed to investigate the effects of α-defensin 1 on electrical field stimulation (EFS)-induced contractions in isolated rat bladder detrusor muscles. We evaluated the effects of α-defensin 1 (50 pM∼5 nM) on EFS-induced contracti
Publikováno v:
European Journal of Pharmacology. 663:74-79
This study was designed to evaluate the effect of jatrorrhizine on smooth muscle contractions isolated from rat ileum longitudinal muscles. Jatrorrhizine increased the amplitude of spontaneous contractions of ileum longitudinal muscles in concentrati
Autor:
Oriana Awwad, Matteo Fornai, Corrado Blandizzi, Luca Antonioli, Narcisa Ghisu, Marco Tuccori, Mario Del Tacca, Rocchina Colucci
Publikováno v:
European Journal of Pharmacology. 650:639-649
This study investigated the expression of A(1) and A(2A) receptors in the rat colonic neuromuscular compartment, and characterized their roles in the control of motility during inflammation. Colitis was induced by 2,4-dinitrobenzenesulfonic acid. A(1
Publikováno v:
European Journal of Pharmacology. 645:158-164
The soluble guanylyl cyclase is expressed in airway smooth muscle, and agents that stimulate this enzyme activity cause airway smooth muscle relaxation and bronchodilation. The compound 5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3
Autor:
Leosvaldo S. M. Velozo, Juliana M Raimundo, Maria Auxiliadora Coelho Kaplan, Gisele Zapata-Sudo, Ana Paula Felix Trindade, Roberto T. Sudo
Publikováno v:
European Journal of Pharmacology. 606:150-154
In Brazilian folk medicine, extracts from Piper species are used to reduce blood pressure. Previously, we demonstrated the vasodilatory activity of crude extracts from leaves of Piper truncatum explaining their possible use in the treatment of hypert
Publikováno v:
European Journal of Pharmacology. 592:151-157
Prostatic A 2A adenosine receptors mediate varied effects. This study aimed to test whether genetic disruption of this receptor affects prostate contractility. Prostates taken from mice which were homozygous (A 2A R−/−) and heterozygous (A 2A R+/
Publikováno v:
European Journal of Pharmacology. 587:216-223
We have investigated the role of nitric oxide (NO) in relaxations to beta-adrenoceptor agonists in mesenteric artery from wild-type (WT) and NO synthase-3 knockout (NOS-3-KO) mice. Isoprenaline, formoterol and BRL 37344 ((R(),R())-(+/-)-4-[2-[(2-(3-c
Publikováno v:
European Journal of Pharmacology. 582:116-122
Septic shock remains the leading cause of death in intensive care units in North America. Recent evidence implicates matrix metalloproteinases (MMP) in the pathogenesis of sepsis. MMP activity is upregulated in blood vessels exposed to bacterial lipo