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Publikováno v:
European Journal of Pharmacology. 740:28-34
Previous studies suggest that β-adrenoceptor stimulation may enhance the cardiac differentiation of mouse embryonic stem (ES) cells. It remains unclear whether the differentiations of ES cells and induced pluripotent stem (iPS) cells rely on similar
Publikováno v:
European Journal of Pharmacology. 714:15-22
Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabo
Autor:
Sho Otake, Tatsuo Kawashima, Risa Yamazaki, Yuta Ikawa, Hiroyuki Nakamura, Erika Yamaura, Yasuo Matsuzawa, Mamoru Takabatake, Hiromichi Fujino, Toshihiko Murayama
Publikováno v:
European Journal of Pharmacology. 696:120-129
Transforming growth factor-β1 (TGFβ1) plays a pivotal role in fibrosis in various organs including the lung. Following pulmonary injury, TGFβ1 stimulates conversion of fibroblasts to myofibroblasts that are mainly characterized by up-regulation of
Publikováno v:
European Journal of Pharmacology. 616:22-30
Cilostazol, a drug commonly used in the treatment of intermittent claudication is a selective phosphodiesterase III inhibitor. It affects cell proliferation, increases cAMP levels, activates the cyclic AMP-dependent protein kinase and inhibits E2F in
Autor:
Mika Scheinin, Anna Huhtinen
Publikováno v:
European Journal of Pharmacology. 587:48-56
A vascular smooth muscle cell line stably expressing the human alpha 2B-adrenoceptor at a density of 1.5 pmol/mg membrane protein was generated by transfection of rat A7r5 cells. [35S]GTPgammaS binding experiments and [3H]thymidine incorporation expe
Publikováno v:
European Journal of Pharmacology. 567:19-25
Recent reports have shown that cytokines inhibit fluid absorption by suppressing Na(+) channel activity in various epithelia. In this study, we investigated the role of epithelial sodium channel (ENaC) in fluid absorption in normal human middle ear e
Publikováno v:
European journal of pharmacology. 761
Several investigators recently identified biased κ opioid receptor (KOP receptor) agonists. However, no comprehensive study of the functional selectivity of available KOP receptor agonists at the human and mouse KOP receptors (hKOP receptor and mKOP
Autor:
Jean Marchand, Sandrine Hilairet, Lluis Fajas, Gérard Le Fur, Monsif Bouaboula, Pierre Casellas
Publikováno v:
European Journal of Pharmacology. 517:174-181
We investigated the effects of anandamide on peroxisome proliferator-activated receptor gamma (PPARgamma) activity. In two different transactivation systems using either full-length or only the ligand binding domain of PPARgamma, we showed that anand
Publikováno v:
European Journal of Pharmacology. 515:34-42
Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human em
Publikováno v:
European Journal of Pharmacology. 427:187-193
The recently cloned protein, calcyon, potentiates crosstalk between G(s)-coupled dopamine D1 receptors and heterologous G(q/11)-coupled receptors allowing dopamine D1 receptors to stimulate intracellular Ca(2+) release, in addition to cAMP production