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Publikováno v:
European Journal of Pharmacology
The spread of the corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been intensifying in the past year, posing a huge threat to global health. There is an urgent need for effectiv
Autor:
Mutsuyoshi Matsushita, Takahisa Yamada, Yoshinori Kosugi, Takeshi Ohta, Takashi Nakagawa, Takahiro Hata, Takafumi Kurimoto, Katsuya Deai, Atsuko Miyai, Yasuo Yamamoto, Isao Tamai
Publikováno v:
European Journal of Pharmacology. 895
Classic glucocorticoids have been prescribed for various inflammatory diseases, such as rheumatoid arthritis, due to their outstanding anti-inflammatory effects. However, glucocorticoids cause numerous unwanted side effects, including osteoporosis an
Autor:
Alexandre Luz de Castro, Denise dos Santos Lacerda, Bruna Gazzi de Lima-Seolin, Patrick Turck, Vanessa Duarte Ortiz, Schauana Freitas Fraga, Alexandre Roberto Hickmann, Alex Sander da Rosa Araujo, Tânia R.G. Fernandes, Adriane Belló-Klein, Rayane Brinck Teixeira
Publikováno v:
European Journal of Pharmacology. 854:159-166
After acute myocardial infarction (AMI), reactive oxygen species and oxidative stress have important roles in the progression to heart failure. As a therapeutic alternative, thyroid hormones (TH) revealed cardioprotective effects after AMI, including
Publikováno v:
European Journal of Pharmacology. 854:179-186
Doxorubicin is a chemotherapeutic agent commonly used to treat breast cancer. However, breast cancer often develops drug resistance, leading to disease recurrence and poor prognosis. Delineating the mechanisms underlying drug resistance is imperative
Publikováno v:
European Journal of Pharmacology. 854:101-108
Management of chronic pain is restricted by the lack of effective tools. This study evaluated the efficacies of sinomenine combined gabapentin or ligustrazine hydrochloride in treating peripheral and central chronic neuropathic pain. The study was co
Autor:
Xiaodong Wang, Huju Chi, Bingbing He, Huali Zheng, Xuanang He, Zhenchao Jin, Bing Liu, Jiali Wang, Hui Qi, Sheng Zhao, Guangyi Jin, Zhulin Wang, Ningning Gao
Publikováno v:
European Journal of Pharmacology. 854:347-353
The cytokine storm includes a clinically heterogeneous set of life-threatening conditions that are manifested by extremely elevated serum cytokine levels and related symptoms (e.g., septic shock) and is devilishly mediated by Toll-like receptor (TLR)
Autor:
James A. Angus, Christine E. Wright
Publikováno v:
European Journal of Pharmacology. 855:124-136
In the pulmonary vasculature there is clearance of endothelin-1 from the circulation mediated by endothelin ETB receptors. This study explored the haemodynamic effects of endothelin-1 and its clearance in the pulmonary and hindquarter vasculature in
Autor:
Bahram Mirani, Saeid Ghavami, Erik Pagan, Mohsen Akbari, Jade Duchscherer, Shahla Shojaei, Brian D. Toyota
Publikováno v:
European Journal of Pharmacology. 854:201-212
Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still remains a major challenge despite the various therapeutic approaches developed over the recent decades. GBM is considered as one of the most therapy-resistant human tumors
Autor:
Francisco Mercado, Francisco Pellicer, Pedro Segura-Chama, Angélica Almanza, Jonathan Mercado-Reyes
Publikováno v:
European Journal of Pharmacology. 853:56-64
Opioids are potent analgesic drugs, but their use has been limited due to their side effects. Antinociceptive effects of D2-like receptor agonists such as quinpirole have been shown at the spinal cord level; however, their efficacy is not as high as
Autor:
Bao-Yan Wu, Ying-Jie Shang, Zhong-Si-Wei Dong, Zhi-Ping Cao, Wen-Xiao Liu, Qi-Yao Liu, Chu-Hua Li
Publikováno v:
European Journal of Pharmacology. 853:325-335
Cerebral ischemia impairs physiological form of synaptic plasticity such as long-term potentiation (LTP). Clinical symptoms of cognitive dysfunction resulting from cerebral ischemia are associated with neuron loss and synaptic function impairment in