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Autor:
Amanda C.S. Sponton, Fábio H. Silva, Fabiano B. Calmasini, Mariana G. de Oliveira, Fabíola Z. Mónica, Edson Antunes, Maria Andréia Delbin, Eduardo C. Alexandre, Diana M. André
Publikováno v:
European Journal of Pharmacology. 836:25-33
Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic a
Autor:
Suliana Mesquita Paula, Carlos Alberto Oliveira-Silva, Mônica de Oliveira Belém, Daniel Maia Nogueira de Oliveira, Emanuella Feitosa de Carvalho, Kalinne Kelly Lima Gadelha, Pedro Jorge Caldas Magalhães, Armênio Aguiar dos Santos, Karine Lima-Silva, Camila Gadelha Pinheiro, Ana Karolina Martins Cavalcante
Publikováno v:
European Journal of Pharmacology. 908:174339
This study tested the effects of β-methylphenylethylamine (β-MPEA) and octopamine on contractile parameters of the gastrointestinal tract in rats. We hypothesized that some of their effects result from interactions with trace amine (TA)-associated
Autor:
Alexander Tamalunas, Annika Herlemann, Beata Rutz, Melanie Schott, Christian G. Stief, Anna Ciotkowska, Qingfeng Yu, Frank Strittmatter, Christian Gratzke, Patrick Keller, Martin Hennenberg, Yiming Wang
Publikováno v:
European Journal of Pharmacology. 803:39-47
Male lower urinary tract symptoms (LUTS) due to bladder outlet obstruction are characterized by abnormal smooth muscle contractions in the lower urinary tract. Alpha1-adrenoceptor antagonists may induce smooth muscle relaxation in the outflow region
Autor:
Alireza Abdollahi, Ahmad Reza Dehpour, Parvin Pasalar, Hedyeh Faghir-Ghanesefat, Nastaran Rahimi, Fatemeh Yarmohmmadi, Nina Javadian, Shahram Ejtemaee-Mehr, Farahnaz Jazayeri
Publikováno v:
European Journal of Pharmacology. 796:39-44
The detrimental cardio-toxic effect of doxorubicin, an effective chemotherapeutic agent, limited its clinical use. It has been claimed that doxorubicin cardio-toxicity occurs through calcium ions (Ca2+) overload and reactive oxygen species production
Autor:
Masamitsu Nakazato, Hideyuki Sakoda, Farhana Naznin, Tadashi Okada, T.M. Zaved Waise, Kenji Arakawa, Hironobu Tsubouchi
Publikováno v:
European Journal of Pharmacology. 794:37-44
Chronic inflammation in systemic organs, such as adipose tissue, nodose ganglion, hypothalamus, and skeletal muscles, is closely associated with obesity and diabetes mellitus. Because sodium glucose cotransporter 2 (SGLT2) inhibitors exert both anti-
Publikováno v:
European Journal of Pharmacology. 791:640-646
Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to
Publikováno v:
European Journal of Pharmacology. 764:318-327
PubMedID: 26169563 Calcium sensitization by the RhoA/Rho-kinase (ROCK) pathway contributes to the contraction in smooth muscle. Contractile stimuli can sensitize myosin to Ca2+ by activating RhoA/Rho-kinase that inhibits myosin light chain phosphatas
Publikováno v:
European Journal of Pharmacology. 872:172951
Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in ta
Autor:
Yaroslav M. Shuba, I. A. Vladimirova, Eugenia M. Kulieva, Natalia Prevarskaya, Ganna V. Sotkis, Yelyzaveta Y. Shuba, Igor B. Philyppov, Roman Skryma, Kseniya L. Gulak
Publikováno v:
European Journal of Pharmacology. 860:172529
Parasympathetic regulation of urinary bladder contractions primarily involves acetylcholine release and activation of detrusor smooth muscle (DSM) muscarinic acetylcholine (mACh) receptors. Co-release of ATP and activation of DSM purinergic P2X1-rece
Autor:
Kamel Gharzouli, Hassiba Benabdallah
Publikováno v:
European Journal of Pharmacology. 760:20-26
The circular smooth muscles of the middle colon of the rabbit generate giant contractions of high amplitude and low frequency. Flavone, at various concentrations, reduces the giant contractions and the tonic contraction induced by 10 µM carbachol an