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Publikováno v:
European journal of pharmacology. 909
The present study intended to investigate whether the activation of cannabinoid CB1 receptors of the ventral tegmental area (VTA), the central amygdala (CeA) and the medial prefrontal cortex (mPFC) could induce conditioned place preference or aversio
Publikováno v:
European journal of pharmacology. 910
Insulin resistance (IR) is the main cause of type 2 diabetes. The liver is the organ where insulin is secreted from the pancreas, and it regulates the storage and release of glucose according to the body's demand. Althouth Loureirin B (LB) has been r
Autor:
Chi-Ming Chu, Tsu Yi Chao, Tsan-Chi Chen, Liang-In Lin, Chung Tay Yao, Hsiu Ling Chou, Chen Hsi Hsieh
Publikováno v:
European Journal of Pharmacology. 846:38-48
Tartrate-resistant acid phosphatase 5a (TRACP5a) is mainly secreted by activated macrophages in chronic inflammation. Serum TRACP5a is associated with symptom distress in lung cancer patients during chemotherapy. Therefore, this study aimed to invest
Autor:
Mohd Akhtar, Mymoona Akhter, Abul Kalam Najmi, Syed Obaidur Rahman, Mohd Salman, Bibhu Prasad Panda, Suhel Parvez, Apeksha Shrivastava, Madhu Kaundal
Publikováno v:
European journal of pharmacology. 889
The complications of Alzheimer's disease (AD) have made the development of its treatment a challenging task. Several studies have indicated the disruption of insulin receptor substrate-1 (IRS-1) signaling during the development and progression of AD.
Publikováno v:
European journal of pharmacology. 876
In the present study, we established the acute lung injury (ALI) model of mice with adrenal insufficiency, and to investigate the possible mechanism by which Icariin (ICA) reduces lipopolysaccharide (LPS) -induced ALI in mice undergoing bilateral adr
Publikováno v:
European Journal of Pharmacology. 829:1-11
Chronic low-grade inflammation plays a major role in the development of insulin resistance. The potential role and underlying mechanism of vitamin C, an antioxidant and anti-inflammatory agent, was investigated in tumor necrosis factor-α (TNF-α)-in
Autor:
Lihuan Guan, Huizhen Zhang, Xiaomei Fan, Leqian Xu, Yixin Chen, Min Huang, Jiahong Sun, Fulin Jiang, Xi Li, Huichang Bi, Dongshun Li, Yawen Zhou, Xuezhen Zeng
Publikováno v:
European Journal of Pharmacology. 818:96-102
Liver regeneration is a vital process of recovery after liver damage, which is a promising clinical strategy after partial hepatectomy (PHx). Schisandrol B (SolB), one of the bioactive ingredients from Schisandra sphenanthera, displays significant he
Publikováno v:
European Journal of Pharmacology. 909:174418
In the present study, first, the role of high-fat diet (HFD) in insulin resistance (IR) in offspring with diabetic and non-diabetic parents, and then the effect of magnesium sulfate (Mg) administration on improved IR in HFD diabetic parents, and thei
Publikováno v:
European Journal of Pharmacology. 813:84-93
Adipose dysfunction links tightly to hepatic insulin resistance and gluconeogenesis. Ilexgenin A is reported with the ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment. Here, we propose that ilexg
Autor:
Hui Wu, Lili Xu, Fang Xu, Qi Xu, Qing Chen, Luyang Wang, Feng Fu, Cuicui Jiao, Xinzhong Chen, Lihong Sun, Xiaowei Qian, Huaqi Yao, Wenxin Zhang, Ying Feng
Publikováno v:
European Journal of Pharmacology. 900:174080
Treatment of visceral pain originating from the uterine cervix is a substantial clinical problem. The underlying mechanisms of such visceral pain remain unclear mainly due to a lack of reliable model. This study aimed to develop and evaluate the perf