Zobrazeno 1 - 10
of 304
pro vyhledávání: ''
Autor:
Sonja I. Buschow, Johannes Textor, Jorieke Weiden, Carl G. Figdor, Georgina Flórez-Grau, Gerty Schreibelt, P. Ben H. Geurtz, I. Jolanda M. de Vries, Marcel M. Verbeek, Jasper J. P. van Beek, Mirjam C van der Net, Rianne van Slooten, Simone P. Sittig
Publikováno v:
European Journal of Immunology
European Journal of Immunology, 51(6), 1494-1504. Wiley-VCH
European Journal of Immunology, 51, 1494-1504
European Journal of Immunology, 51, 6, pp. 1494-1504
European Journal of Immunology, 51(6), 1494-1504. Wiley-VCH
European Journal of Immunology, 51, 1494-1504
European Journal of Immunology, 51, 6, pp. 1494-1504
Dendritic cells (DCs) are key regulators of the immune system that shape T cell responses. Regulation of T cell induction by DCs may occur via the intracellular enzyme indoleamine 2,3‐dioxygenase 1 (IDO), which catalyzes conversion of the essential
Autor:
Dennis M. Klinman, Christian Bode, Jens M. Poth, Folkert Steinhagen, Eicke Latz, Mario Fox, Susanne Schulz
Publikováno v:
European Journal of Immunology. 51:1686-1697
Cytosolic DNA receptor cyclic GMP-AMP (cGAMP) synthase (cGAS) has been shown to be critically involved in the detection of cytosolic, self- and non-self-DNA, initiating a type I Interferon (IFN) response through the adaptor protein Stimulator of Inte
Autor:
Jean-Sébastien Delisle, Mengqi Dong, Nienke Vrisekoop, Heather J. Melichar, Judith N. Mandl, Marie-Ève Lebel, Suzanne J Vobecky, Marilaine Fournier, Elie Haddad, Aditi Sood
Publikováno v:
European Journal of Immunology
Studies in murine models show that subthreshold TCR interactions with self‐peptide are required for thymic development and peripheral survival of naïve T cells. Recently, differences in the strength of tonic TCR interactions with self‐peptide, a
Publikováno v:
European Journal of Immunology
HAMLET is a protein‐lipid complex with a specific and broad bactericidal and tumoricidal activity, that lacks cytotoxic activity against healthy cells. In this study, we show that HAMLET also has general immune‐stimulatory effects on primary huma
Autor:
Maria Ntinopoulou, Aristea Batsali, Helen A. Papadaki, Konstantinos Ritis, Alexandros Mitsios, Victoria Tsironidou, Charalampos Papagoras, Panagiotis Skendros, Akrivi Chrysanthopoulou
Publikováno v:
European Journal of Immunology. 51:930-942
Ankylosing spondylitis (AS) is an inflammatory disease characterized by excessive bone formation. We investigated the presence of neutrophil extracellular traps (NETs) in AS and how they are involved in the osteogenic capacity of bone marrow mesenchy
Autor:
Thomas H. Wesselink, Klaas P. J. M. van Gisbergen, Natasja A. M. Kragten, Astrid A. Bovens, Regina Stark, René A. W. van Lier, Felix M. Behr
Publikováno v:
European journal of immunology, 50(10), 1515-1524. Wiley-VCH Verlag
Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to immunosurveillance as well as pathogenesis of the liver. Systemic activation of iNKT cells induces acute immune-mediated liver injury. However, how ti
Autor:
Leonid Margolis, Michael M. Lederman, Alexey A. Komissarov, Daria Potashnikova, Vladimir Gontarenko, Derenik Maytesyan, Elena Vasilieva, Michael L. Freeman
Publikováno v:
European Journal of Immunology. 51:1857-1859
T-cell accumulation in atherosclerotic plaques contributes to plaque destabilization. We found that several chemokine receptors are differentially expressed on peripheral blood compared to plaque-resident T cells and corresponding ligands are upregul
Autor:
Beatriz Malvar Fernandez, Weiyang Tao, Sandra C Silva-Cardoso, Marianne Boes, Timothy R D J Radstake, Aridaman Pandit
Publikováno v:
European Journal of Immunology
RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profi
Autor:
Leonie S. Taams, Michael Ridley, Shahram Kordasti, Giovanni A M Povoleri, Shweta Agrawal, Kathryn J. A. Steel, Ceri A. Roberts, Aoife M O'Byrne, Sylvine Lalnunhlimi, Klaus Stensgaard Frederiksen
Publikováno v:
European Journal of Immunology
Povoleri, G A M, Lalnunhlimi, S, Steel, K J A, Agrawal, S, O'Byrne, A, Ridley, M, Kordasti, S, Frederiksen, K S, Roberts, C A & Taams, L S 2020, ' Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype ', European Journal of Immunology, vol. 50, no. 3, pp. 445-458 . https://doi.org/10.1002/eji.201948190
Povoleri, G A M, Lalnunhlimi, S, Steel, K J A, Agrawal, S, O'Byrne, A, Ridley, M, Kordasti, S, Frederiksen, K S, Roberts, C A & Taams, L S 2020, ' Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype ', European Journal of Immunology, vol. 50, no. 3, pp. 445-458 . https://doi.org/10.1002/eji.201948190
TNF‐blockade has shown clear therapeutic value in rheumatoid arthritis and other immune‐mediated inflammatory diseases, however its mechanism of action is not fully elucidated. We investigated the effects of TNF‐blockade on CD4+ T cell activati
Autor:
Annkathrin C. Teschner, Sandra Beer-Hammer, Katja Fromm, Nikolaus Rieber, Dominik Hartl, Felipe J.N. Lelis, Jennifer Jaufmann
Publikováno v:
European Journal of Immunology. 50:33-47
Myeloid-derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T-cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not lim