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Autor:
Akos Heinemann, Bernhard A. Peskar, Sonia Philipose, Zoltán Bálint, Rufina Schuligoi, Andrea Olschewski, Rudolf Schicho, Eva M. Sturm, Gunther Marsche, Viktoria Konya
Publikováno v:
European Journal of Immunology. 41:2379-2389
Eosinophil extravasation across the endothelium is a key feature of allergic inflammation. Here, we investigated the role of PGE(2) and its receptor, E-type prostanoid receptor (EP)-4, in the regulation of eosinophil interaction with human pulmonary
Autor:
Joyce M. Koenig, Daniel F. Hoft, Yanping Zhang, Jian Ye, Eddy C. Hsueh, Guangyong Peng, Xinming Su
Publikováno v:
European Journal of Immunology. 41:936-951
Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described.
Autor:
Paloma Sánchez-Mateos, María Rodríguez-Martínez, Lucía Sánchez-Ruiloba, José Luis Rodríguez-Fernández, Miguel R. Campanero, Roberto Martín Jean-Mairet, Sandra Sacristán, Celia López-Menéndez, Francisco Sánchez-Madrid, Lorena Riol-Blanco, Teresa Iglesias
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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12 páginas, 7 figuras.-- et al.
Kinase D interacting substrate of 220kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is a protein that is mainly expressed in brain and neural cells where its function is only startin
Kinase D interacting substrate of 220kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is a protein that is mainly expressed in brain and neural cells where its function is only startin
Autor:
Nele Berghmans, Jozef Van Damme, Christophe Vanormelingen, Mieke Gouwy, Dominique Schols, Sofie Struyf
Publikováno v:
European Journal of Immunology. 41:963-973
One of the most important functions of chemokines and their receptors is the regulation of directional migration of leukocytes within tissues. In specific tissue compartments, cells are exposed to multiple chemokines presented in complex dimensional
Autor:
Sander Hoosemans, I. Jolanda M. de Vries, Alessandra Cambi, Jurjen Tel, Gosse J. Adema, Daniel Benitez-Ribas, Carl G. Figdor, Paul J. Tacken
Publikováno v:
European Journal of Immunology, 41, 1014-23
European Journal of Immunology, 41, 4, pp. 1014-23
European Journal of Immunology, 41, 4, pp. 1014-23
Contains fulltext : 97777.pdf (Publisher’s version ) (Open Access) DEC-205 is a type I C-type lectin receptor (CLR) that is expressed on various APC subsets and has been suggested to bind necrotic and apoptotic cells. Here we study DEC-205 characte
Publikováno v:
European Journal of Immunology. 41:47-59
IL-27 has been shown to exhibit both pro- and anti-inflammatory properties; it favors mouse naïve CD4(+) T-cell differentiation into Th1 cells to the detriment of Th17 and Th2 skewing and regulates IL-10 and IL-17 production by human CD4(+) T cells.
Publikováno v:
European Journal of Immunology. 41:195-201
Human Vγ9Vδ2 T cells are potent anti-tumor lymphocytes that specifically respond to pyrophosphate (phospho-) antigens, which constitute the basis of current γδ T-cell-based immunotherapy strategies. Despite a clear involvement of the TCR, the cos
Autor:
Alicia Aranguren, Esther Larrea, Ignacio Melero, Asis Palazon, Juan Dubrot, Uxua Mancheño, José-Ignacio Riezu-Boj, Izaskun Gabari, Jesús Prieto, Iranzu González, Sandra Hervas-Stubbs, Juan Carlos Ruiz, Arantza Azpilicueta
Publikováno v:
European Journal of Immunology. 40:3389-3402
IFN-α/β link innate and adaptive immune responses by directly acting on naïve CD8(+) T cells. This concept unveiled in mice remains unexplored in humans. To investigate that, human CD8(+) CD45RO(-) cells were stimulated with beads coated with anti
Publikováno v:
European Journal of Immunology. 40:3557-3569
TLR, expressed on the surface of mast cells, respond to a variety of bacterial and viral components to induce and enhance high-affinity IgE receptor-mediated cytokine production. Recent reports have indicated that specific TLR-dependent responses in
Autor:
Nicolò Costantino Brembilla, Carlo Chizzolini, Jean-Marie Ramirez, Eddy Roosnek, Thomas Matthes, Rachel Chicheportiche, Jean-Michel Dayer, Jean-Hilaire Saurat, Olivier Sorg
Publikováno v:
European journal of immunology
European Journal of Immunology, Vol. 40, No 9 (2010) pp. 2450-2459
European Journal of Immunology, Vol. 40, No 9 (2010) pp. 2450-2459
Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T-cell polarization. We found that