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Autor:
Emily M Flowers, Harold R. Neely, Tereza Almeida, Caitlin D. Castro, Yuko Ohta, Martin F. Flajnik, Jacqueline Guo
Publikováno v:
Eur J Immunol
The poly-Immunoglobulin Receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously ann
Publikováno v:
Eur J Immunol
Stearoyl-CoA desaturases (SCD) are endoplasmic reticulum (ER)-associated enzymes that catalyze the synthesis of the monounsaturated fatty acids (MUFAs). As such, SCD play important roles in maintaining the intracellular balance between saturated fatt
Autor:
Elizabeth E. Waffarn, Markus Hoelzl, Hao Wei Li, Megan Sykes, Nichole Danzl, Rachel C. Madley, Mohsen Khosravi-Maharlooei
Publikováno v:
Eur J Immunol
We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is c
Publikováno v:
Eur J Immunol
AIM2 is a cytosolic innate immune receptor which recognizes double-stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of dsDNA leads to the assembly of a large multiprotein oligomeric complex termed th
Publikováno v:
European Journal of Immunology. 48:1607-1620
There are over 10 trillion endothelial cells (EC) that line the vasculature of the human body. These cells not only have specialized functions in the maintenance of homeostasis within the circulation and various tissues but they also have a major rol
Autor:
Adrian J. Thrasher, Elizabeth Rivers
Publikováno v:
Eur J Immunol
The Wiskott-Aldrich syndrome protein (WASP) participates in innate and adaptive immunity through regulation of actin cytoskeleton-dependent cellular processes, including immune synapse formation, cell signaling, migration and cytokine release. There
Autor:
Adam Mor, Inbar Azoulay-Alfaguter
Publikováno v:
European Journal of Immunology. 48:1915-1917
Exosomes are cell-derived vesicles that have been implicated in the pathogenesis of many inflammatory diseases. More specifically, it has been shown that T cell-derived exosomes can induce immunological responses; however, little is known about the m
Autor:
Ravi K. Dinesh, Daniel A. Michelson, Benjamin Barnhill, David G. Schatz, Donald F. Hunt, Anoj Ilanges, Jukka Alinikula, Jeffrey Shabanowitz, Lizhen Wu, Filip Šenigl
Publikováno v:
Eur J Immunol
Secondary diversification of the immunoglobulin (Ig) repertoire occurs through somatic hypermutation (SHM), gene conversion (GCV), and class switch recombination (CSR)—three processes that are initiated by activation-induced cytidine deaminase (AID
Autor:
Shunbin Ning, Juan Zhao, Ling Wang, Junping Ren, Jonathan P. Moorman, Kenton Hall, Zhi Q. Yao
Publikováno v:
European Journal of Immunology. 46:2409-2419
Interferon (IFN) regulatory factor 7 (IRF7) plays a key role in the production of IFNα in response to viral infection, and phosphorylation at IRF7 C-terminal serine sites is prelude to its function. However, no phosphatases which that may be involve
Publikováno v:
European Journal of Immunology. 46:1948-1958
Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show eleva