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Autor:
Jean-François Daudelin, Heather J. Melichar, Réjean Lapointe, Mélissa Mathieu, Léa Gaudot, Livia Odagiu, Nathalie Labrecque
Publikováno v:
European journal of immunology. 47(2)
Vaccination with antigen-pulsed CD40-activated B (CD40-B) cells can efficiently lead to the in vivo differentiation of naive CD8+ T cells into fully functional effectors. In contrast to bone marrow-derived dendritic cell (BMDC) vaccination, CD40-B ce
Publikováno v:
European Journal of Immunology. 41:47-59
IL-27 has been shown to exhibit both pro- and anti-inflammatory properties; it favors mouse naïve CD4(+) T-cell differentiation into Th1 cells to the detriment of Th17 and Th2 skewing and regulates IL-10 and IL-17 production by human CD4(+) T cells.
Autor:
Alicia Aranguren, Esther Larrea, Ignacio Melero, Asis Palazon, Juan Dubrot, Uxua Mancheño, José-Ignacio Riezu-Boj, Izaskun Gabari, Jesús Prieto, Iranzu González, Sandra Hervas-Stubbs, Juan Carlos Ruiz, Arantza Azpilicueta
Publikováno v:
European Journal of Immunology. 40:3389-3402
IFN-α/β link innate and adaptive immune responses by directly acting on naïve CD8(+) T cells. This concept unveiled in mice remains unexplored in humans. To investigate that, human CD8(+) CD45RO(-) cells were stimulated with beads coated with anti
Publikováno v:
European Journal of Immunology. 40:1628-1638
Evidence is presented that thermal or oxidizing stress-activated DC interact with CD4(+) T cells to induce and maintain a TCR-independent homeostatic memory circuit. Stress-activated DC expressed endogenous intra-cellular and cell surface HSP70. The
Autor:
Stefan Bluml, Otto Majdic, Olga Oskolkova, Stefanie Kirchberger, Valery N. Bochkov, Maria Seyerl, Johannes Stöckl
Publikováno v:
European Journal of Immunology. 38:778-787
Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cel
Publikováno v:
European Journal of Immunology. 37:1129-1138
The formation of immunological memory is a hallmark of adaptive immunity and the goal of vaccination. For CD8(+ )T cells, successful generation of memory cells has been linked to IL-7 receptor alpha (IL-7Ralpha) expression, suggesting a role for IL-7
CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65
Autor:
William W. Kwok, Eddie A. James
Publikováno v:
European Journal of Immunology. 37:78-86
Although potentially autoreactive T cells are present even in healthy subjects, most individuals do not develop autoimmune disease. It has been well demonstrated that CD4+ CD25+ regulatory T cells play a significant role in controlling the expansion
Autor:
Mathias Krummen, Sandra Balkow, Frank van den Boom, Stephan Grabbe, Tobias Rothoeft, Stefan Beissert, Karin Loser, Georg Varga, Pia Oberbanscheidt
Publikováno v:
European Journal of Immunology. 36:3105-3117
The adaptive immune response is initiated when naive T cells interact with dendritic cells (DC). However, the physicodynamics as well as the molecules that constitute the contact plane (immunological synapse) between DC and T cells are not well under
Autor:
Andreas Krueger, Kathrin Kappes, Henning Schulze-Bergkamen, Stefanie C. Fas, Christian R. Frey, Peter H. Krammer, Christine Stumpf, Dirk Brenner, Sven Baumann
Publikováno v:
European Journal of Immunology. 36:2894-2903
An adaptive immune response implies expansion of activated T cells and subsequent elimination to maintain homeostasis in a process called activation-induced cell death. Some cells, however, differentiate into memory cells and ensure a strong secondar
Autor:
Ivan C. Moura, Yves Lepelletier, Olivier Hermine, Cédric Baude, Réda Hadj-Slimane, Anat Shirvan, Susana Fiorentino, Amédée Renand, Ari Barzilai
Publikováno v:
European Journal of Immunology. 36:1782-1793
Timely negative regulation of the immune system is critical to allow it to perform its duty while maintaining it under tight control to avoid overactivation. We previously reported that the neuronal receptor neuropilin-1 (NP-1) is expressed in human