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Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 9:149-153
Two doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay. Only an insignificant fraction o
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 12(3)
Amikacin levels in serum and tissues were determined in 115 Wistar rats, 70 with normal renal function (NRF) and the remaining 45 with terminal renal impairment (TRI). The results obtained in the animals with NRF show an accumulation of the antibioti
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 8(4)
Cimoxatone is a reversible mixed-type selective inhibitor of monoamine oxidase-A. For a mixed-type inhibitor, it can be shown that (vo-vi)/Vi is proportional to the inhibitor concentration. This relationship has been used to estimate the t 1/2 of the
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 13(1)
[14C]carbisocaine, N-(2-(2-[1-14C]-heptyloxyphenylcarbamoyloxy)-propyl)-diethylammoni um chloride was administered to male Wistar rats, weighing 180-210 g IV in doses of 0.425, 1.425, 2.425 or 4.425 mg/kg or orally in a dose of 2.425 mg/kg. Extractio
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 8(3)
The aim of the present study was to investigate an eventual influence of the hour of administration on lidocaine kinetics in the rat. 280 Wistar AF-SPF adult male rats were used for this study and maintained under controlled environmental conditions