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Publikováno v:
European Journal of Clinical Pharmacology. 77:1333-1339
Warfarin-associated coagulopathy commonly occurs in patients undergoing treatment with this anticoagulant. This trial aimed to determine the efficacy of using low-dose orally administered vitamin K1 to lower international normalized ratio (INR) value
Autor:
Laurent A. Decosterd, Thierry Buclin, Catia Marzolini, Monia Guidi, Chantal Csajka, Perrine Courlet, Susana Alves Saldanha, Matthias Cavassini, Marcel Stoeckle
Publikováno v:
European Journal of Clinical Pharmacology
European journal of clinical pharmacology, vol. 77, no. 7, pp. 979-987
European journal of clinical pharmacology, vol. 77, no. 7, pp. 979-987
Purpose Drug-drug interactions (DDIs) with antiretroviral drugs (ARVs) represent an important issue in elderly people living with HIV (PLWH). Amlodipine is a commonly prescribed antihypertensive drug metabolized by CYP3A4, thus predisposed to a risk
Autor:
Arash Raoufinia, Dean F. Wong, James Robert Brašić, Robert A. Forbes, Robert D. McQuade, Hiroto Kuwabara, Tetsuro Kikuchi, Patricia Bricmont
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D2/D3 receptor occupancy induced by the serotonin–dopamine activity modulator, brexpiprazole, at different single dose lev
Autor:
Inge R F van Berlo-van de Laar, Frank G A Jansman, Marjo van den Elsen-Hutten, Cornelis G Vermeij, Katja Taxis, Arthur de Meijer
Publikováno v:
European Journal of Clinical Pharmacology, 76(6), 815-820. Springer Verlag
European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
Purpose To assess whether extracorporeal treatment (ECTR) improves outcome of patients with metformin-associated lactic acidosis (MALA) and to evaluate the clinical applicability of the Extracorporeal Treatments in Poisoning Workgroup (EXTRIP) criter
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Peficitinib is an oral pan-Janus kinase inhibitor for the treatment of rheumatoid arthritis. Co-administration of peficitinib with metformin, a type 2 diabetes therapy, can occur in clinical practice. Hepatic and renal uptake of metformin is
Publikováno v:
European Journal of Clinical Pharmacology. 76:1169-1174
Paradoxical adverse drug reactions (ADRs) are defined as being opposing reactions to the pharmacological effect of drugs in relation to its pharmacodynamic properties. Their diagnosis is difficult as they are relatively rare with atypical clinical pr
Publikováno v:
European Journal of Clinical Pharmacology. 76:723-729
In this study, the risk factors associated with sodium overcorrection were investigated with an optimal cutoff for baseline serum sodium for use in daily clinical practice. Electronic medical records of patients who received tolvaptan for non-hypovol
Autor:
Thilo Bertsche, Carolin Dietze, Ines Gockel, Thorsten Kaiser, Sirak Petros, Susanne Schiek, Christoph Josten, Yvonne Remane, Christian Pfrepper
Publikováno v:
European Journal of Clinical Pharmacology. 76:483-490
Metamizole can sterically inhibit aspirin (ASA) from binding to cyclooxygenase 1 (COX1). It is recommended that ASA should be taken 30 min prior to metamizole to maintain the irreversible inhibition of arachidonic acid (AA)–induced platelet aggrega
Autor:
Anne Gardin, Swati Dumitras, Srikanth Neelakantham, Felix Huth, Andrea Feller, Kasra Shakeri-Nejad
Publikováno v:
European Journal of Clinical Pharmacology. 75:1565-1574
To evaluate the PK and safety of siponimod, a substrate of CYP2C9/3A4, in the presence or absence of a CYP3A4 inhibitor, itraconazole. This was an open-label study in healthy subjects (aged 18–50 years; genotype: CYP2C9 *1*2 [cohort 1; n = 17] or *
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo