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Publikováno v:
European Journal of Clinical Pharmacology
Purpose To examine the impact of new controlled drugs legislation introduced in May 2017 on benzodiazepine receptor agonist (BZRA) prescribing in Ireland. Methods A repeated cross-sectional analysis was conducted using publically available monthly ph
Autor:
Farzad Kobarfard, Mehran Kouchek, Seyedpouzhia Shojaei, Fatemeh Nezarat, Mohammad Sistanizad, Azadeh Ahmadi Koomleh, Sara Salarian, Elham Pourheidar, Mir Mohammad Miri, Shadi Ziaie, Rezvan Hassanpour
Publikováno v:
European Journal of Clinical Pharmacology
Purpose No study has been evaluated pharmacokinetic (PK) and pharmacodynamic (PD) properties of β-lactam antibiotics in patients with acute kidney injury (AKI), not requiring renal replacement therapy (RRT). We evaluated the time that plasma concent
Autor:
Jonatan D. Lindh, Buster Mannheimer, Cecilia Fahlén Bergh, Henrik Falhammar, Jakob Skov, Jan Calissendorff
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Thiazide diuretics are the most common origin of drug-induced hyponatremia. However, population-based studies on clinical outcomes are lacking. We therefore explored the time course and absolute risk of thiazide-associated hospitalization due
Autor:
Hirotoshi Echizen, Tokujiro Uchida, Hirokuni Arai, Tomohiro Mizuno, Koshi Makita, Mizuho Asada, Shinichi Kijima, Masato Yasuhara, Hiromitsu Takahashi, Masashi Nagata
Publikováno v:
European Journal of Clinical Pharmacology. 77:735-745
The aims of the present study were to establish a population pharmacokinetic (PPK) model of cefazolin for adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and to assess the probability of target attainment (PTA) for the pro
Autor:
Ting Cai, Jing Lin, Xiaoyu Yan, Shun Zhang, Xueting Yao, Qi Liu, Haiyan Li, Dongyang Liu, Cheng Cui, Xiaoxu Wang, Zhe Hou, Zi Xiong, Xiaohan Wang
Publikováno v:
European Journal of Clinical Pharmacology
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible
Autor:
Lobna Laroussi, Neila Ben Romdhane, Amine Boussofara, Afef Ben Halima, Salem Kachboura, H. Baccouche, E. Bennour, Ibn El Haj Zied, Ikram Kammoun, Hbib Triki, Sami Kasbaoui, F. Addad, Sonia Marrakchi
Publikováno v:
European Journal of Clinical Pharmacology. 77:517-526
Diabetes is associated with a high rate of events after acute coronary syndrome. It was recently reported that once-daily aspirin might not provide stable biological efficacy in patients with diabetes. We sought to compare the biological efficacy of
Publikováno v:
European Journal of Clinical Pharmacology. 76:711-718
Purpose Antipsychotics are first-line treatment of schizophrenia. They are often accompanied by adjunctive treatments, such as antidepressant (AD) or mood stabilizer (MS), although there is only limited information of their use in first-episode schiz
Autor:
Qian Wang, Wei Guo, Bao Shuang, Yan Wang, Fang Dong, Yan-Nan Zang, Can-Jun Ruan, An-Ning Li, Meng-Xi Niu
Publikováno v:
European journal of clinical pharmacology. 78(3)
PURPOSE To develop and validate a population pharmacokinetic (PPK) model of valproic acid (VPA) in adult Chinese patients with bipolar disorder, and provide guidance for individualized therapy in this population. METHODS A total of 1104 serum concent
Publikováno v:
European Journal of Clinical Pharmacology. 75:1547-1553
Considering the very limited while varying information about the excretion of hydroxychloroquine (HCQ) into human milk, we sought to determine the breast milk concentrations of HCQ in Chinese lactating patients with connective tissue diseases to asse
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo