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Autor:
Jonatan D. Lindh, Buster Mannheimer, Cecilia Fahlén Bergh, Henrik Falhammar, Jakob Skov, Jan Calissendorff
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Thiazide diuretics are the most common origin of drug-induced hyponatremia. However, population-based studies on clinical outcomes are lacking. We therefore explored the time course and absolute risk of thiazide-associated hospitalization due
Publikováno v:
European Journal of Clinical Pharmacology, 77 (6)
European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
Purpose In response to a large trial, the World Health Organization broadened their recommendation on tranexamic acid to be used for post-partum hemorrhage. A 2013 French periodic safety update report warned of an abnormally high rate of renal cortic
Autor:
Bernhard J. Connemann, Michael Denkinger, Emaad Abdel-Kahaar, Carlos Schönfeldt-Lecuona, Maximilian Gahr, Mohamed Elsayed
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Most psychiatric drugs, such as antidepressants (AD) and antipsychotics (AP), may cause cardiac adverse events (CAE). We used summaries of product characteristics (SmPC) for assessing the likelihood of AD and AP to cause CAE. Methods We ident
Autor:
Hirotoshi Echizen, Tokujiro Uchida, Hirokuni Arai, Tomohiro Mizuno, Koshi Makita, Mizuho Asada, Shinichi Kijima, Masato Yasuhara, Hiromitsu Takahashi, Masashi Nagata
Publikováno v:
European Journal of Clinical Pharmacology. 77:735-745
The aims of the present study were to establish a population pharmacokinetic (PPK) model of cefazolin for adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and to assess the probability of target attainment (PTA) for the pro
Publikováno v:
European Journal of Clinical Pharmacology. 77:671-676
Ketamine has rapid-onset antidepressant effects in patients with treatment-resistant depression. Common side effects include dissociation (a sense of detachment from reality) and increases in systolic and diastolic blood pressure. The objective of th
Autor:
Devin Michael Absher, Thiago José Dionísio, Carlos Ferreira dos Santos, Giovana Maria Weckwerth, Leonardo Rigoldi Bonjardim, Elza Araujo Torres, Yuri Martins Costa, Gabriela M. Oliveira, Troy Moore, Bella L. Colombini-Ishiquiriama, Adriana Maria Calvo
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
This study hypothesized that drugs accumulate in the bloodstream of poor-metabolizing patients and may have more adverse effects and different pain perceptions and aimed to investigate the influence of CYP450 polymorphisms on acute postoperative pain
Autor:
Arash Raoufinia, Dean F. Wong, James Robert Brašić, Robert A. Forbes, Robert D. McQuade, Hiroto Kuwabara, Tetsuro Kikuchi, Patricia Bricmont
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D2/D3 receptor occupancy induced by the serotonin–dopamine activity modulator, brexpiprazole, at different single dose lev
Autor:
Ting Cai, Jing Lin, Xiaoyu Yan, Shun Zhang, Xueting Yao, Qi Liu, Haiyan Li, Dongyang Liu, Cheng Cui, Xiaoxu Wang, Zhe Hou, Zi Xiong, Xiaohan Wang
Publikováno v:
European Journal of Clinical Pharmacology
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible
Autor:
Wilhelm Huisinga, Oliver Scherf-Clavel, Madelé van Dyk, Alwin D. R. Huitema, Ulrich Jaehde, Stefanie L. Groenland, Robin Michelet, Neeltje Steeghs, Charlotte Kloft, Anna Mueller-Schoell
Publikováno v:
European Journal of Clinical Pharmacology
Purpose This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the pharmacokinetic exposure in OAD ther
Autor:
Pardis Ziaeefar, Akram Sadat Razavizadeh, Hossein Hassanian-Moghaddam, Sara Ebrahimi, Nasim Zamani
Publikováno v:
European Journal of Clinical Pharmacology. 77:547-554
We aimed to investigate the efficacy of flumazenil infusion in the maintenance of arousal and prevention of development of complications in severe benzodiazepine poisoning. Sixty severely poisoned patients (intubated due to loss of consciousness) int