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Publikováno v:
European Journal of Clinical Pharmacology. 77:1157-1168
Variability in teicoplanin pharmacokinetics has been explained by multiple factors such as body weight, renal function, and serum albumin level. To improve mechanistic understanding of the causes of variability, a physiologically based pharmacokineti
Publikováno v:
European Journal of Clinical Pharmacology
Purpose U.S. Food and Drug Administration (FDA) recommended telavancin dosing is based on total body weight (TBW) but lacks adjusted regimens for obese subjects with varying renal function. Our aim was to develop a physiologically based pharmacokinet
Autor:
Laurent A. Decosterd, Thierry Buclin, Catia Marzolini, Monia Guidi, Chantal Csajka, Perrine Courlet, Susana Alves Saldanha, Matthias Cavassini, Marcel Stoeckle
Publikováno v:
European Journal of Clinical Pharmacology
European journal of clinical pharmacology, vol. 77, no. 7, pp. 979-987
European journal of clinical pharmacology, vol. 77, no. 7, pp. 979-987
Purpose Drug-drug interactions (DDIs) with antiretroviral drugs (ARVs) represent an important issue in elderly people living with HIV (PLWH). Amlodipine is a commonly prescribed antihypertensive drug metabolized by CYP3A4, thus predisposed to a risk
Autor:
Hirotoshi Echizen, Tokujiro Uchida, Hirokuni Arai, Tomohiro Mizuno, Koshi Makita, Mizuho Asada, Shinichi Kijima, Masato Yasuhara, Hiromitsu Takahashi, Masashi Nagata
Publikováno v:
European Journal of Clinical Pharmacology. 77:735-745
The aims of the present study were to establish a population pharmacokinetic (PPK) model of cefazolin for adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and to assess the probability of target attainment (PTA) for the pro
Autor:
Ting Cai, Jing Lin, Xiaoyu Yan, Shun Zhang, Xueting Yao, Qi Liu, Haiyan Li, Dongyang Liu, Cheng Cui, Xiaoxu Wang, Zhe Hou, Zi Xiong, Xiaohan Wang
Publikováno v:
European Journal of Clinical Pharmacology
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Drug-drug interaction (DDI) potentials of lusutrombopag, a thrombopoietin receptor agonist, on the activity of cytochrome P450 (CYP) 3A and of cyclosporine, which inhibits P-glycoprotein and breast cancer resistance protein, on lusutrombopag
Autor:
Li-Yuan Tian, Min Kan, Baoping Xu, Hai-Yan Shi, Evelyne Jacqz-Aigrain, Ya-Kun Wang, Wei Zhao, Bo-Hao Tang, Adong Shen, Yi Zheng, Muhammad Wasim Khan, Yue-E Wu
Publikováno v:
European Journal of Clinical Pharmacology. 76:1547-1556
To assess ceftriaxone population pharmacokinetics in a large pediatric population and describe the proper dose for establishing an optimized antibiotic regimen. From pediatric patients using ceftriaxone, blood samples were obtained and the concentrat
Publikováno v:
European Journal of Clinical Pharmacology. 76:821-831
Higher drug concentrations in complex clinical scenarios in which multiple factors such as drug–drug interactions (DDIs) and comorbidities are simultaneously present are not necessarily rationalized in prospective clinical studies. Physiologically
Publikováno v:
European Journal of Clinical Pharmacology. 75:1219-1226
Vancomycin is commonly used for the management of severe infections; however, vancomycin dosing may be challenging in critically ill patients. This observational study aims to describe the population pharmacokinetics of vancomycin in adult patients w
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo