Zobrazeno 1 - 10
of 46
pro vyhledávání: ''
Autor:
Yuichi Kojima, Takako Miyazaki, Kazuhide Higuchi, Yuki Hirata, Yasuhiro Ueda, Shiro Nakamura, Hiroyuki Tsujimoto, Kazuki Kakimoto, Ryoji Koshiba, Toshihisa Takeuchi, Kazuhiro Ota, Naohiko Kinoshita, Yasuyoshi Tanaka, Hideki Tawa
Publikováno v:
European Journal of Clinical Pharmacology. 77:1639-1648
Low-dose aspirin (LDA) administration prevents cerebral infarction and myocardial infarction, but many studies found an association with mucosal injury. Proton-pump inhibitors (PPIs) can prevent gastric and duodenal mucosal damage, but they may exace
Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low
Autor:
Lars L. Gustafsson, Josefine Nasiell, Anton Pohanka, Mats Blennow, Margareta Blomdahl-Wetterholm, M. Hovstadius, Katarina Wide, Essi Heinonen
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Sertraline, a selective serotonin reuptake inhibitor (SSRI), is one of the most commonly used antidepressant during pregnancy. Plasma sertraline concentrations vary markedly between individuals, partly explained by variability in hepatic drug
Publikováno v:
European Journal of Clinical Pharmacology. 77:1201-1208
Paliperidone palmitate is an antipsychotic medication available as long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age and gender on paliperidone exposure after administration of LAI formulations. Dat
Autor:
Shuran Yu, Zi-ran Li, Boting Zhou, Min Zhu, Changcheng Sheng, Xurui Gu, Zheng Jiao, Yani Hu, Mubai Ma, Qilin Peng
Publikováno v:
European Journal of Clinical Pharmacology. 77:999-1009
The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication. A total of 313 patients were included and both their
Autor:
Wilhelm Huisinga, Oliver Scherf-Clavel, Madelé van Dyk, Alwin D. R. Huitema, Ulrich Jaehde, Stefanie L. Groenland, Robin Michelet, Neeltje Steeghs, Charlotte Kloft, Anna Mueller-Schoell
Publikováno v:
European Journal of Clinical Pharmacology
Purpose This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the pharmacokinetic exposure in OAD ther
Publikováno v:
European Journal of Clinical Pharmacology, 1667-1673. Springer Verlag
ISSUE=12;STARTPAGE=1667;ENDPAGE=1673;ISSN=0031-6970;TITLE=European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
ISSUE=12;STARTPAGE=1667;ENDPAGE=1673;ISSN=0031-6970;TITLE=European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
Purpose Tacrolimus and everolimus are widely used to prevent allograft rejection. Both are metabolized by the hepatic cytochrome P450 (CYP) enzyme CYP3A4 and are substrate for P-glycoprotein (P-gp). Drugs influencing the activity or expression of CYP
Publikováno v:
European Journal of Clinical Pharmacology
Purpose To evaluate the penetration of levofloxacin and dexamethasone sodium phosphate into the aqueous humour (AH) after administration in combination and as single molecules. Evaluation of the penetration of those agents in the site of action and t
Publikováno v:
European Journal of Clinical Pharmacology. 76:41-49
Tailoring medication dosing for the individual patient is complex, and many factors can influence drug exposure. We investigated the effect of age and CYP2D6 genotype on aripiprazole and dehydroaripiprazole exposure in patients using long-acting inje
Autor:
Maria Chrzanowska, Tomasz Pawinski, Danuta Ostalska-Nowicka, Paweł Żero, Matylda Resztak, Joanna Sobiak, Jacek Zachwieja
Publikováno v:
European Journal of Clinical Pharmacology. 75:1249-1259
Limited sampling strategy (LSS) is a precise and relatively convenient therapeutic drug monitoring method. We evaluated LSSs for mycophenolic acid (MPA) in children with nephrotic syndrome treated with mycophenolic mofetil (MMF) and validated the LSS
Publikováno v:
European Journal of Clinical Pharmacology. 75:1219-1226
Vancomycin is commonly used for the management of severe infections; however, vancomycin dosing may be challenging in critically ill patients. This observational study aims to describe the population pharmacokinetics of vancomycin in adult patients w