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Publikováno v:
European Journal of Clinical Pharmacology. 77:1157-1168
Variability in teicoplanin pharmacokinetics has been explained by multiple factors such as body weight, renal function, and serum albumin level. To improve mechanistic understanding of the causes of variability, a physiologically based pharmacokineti
Publikováno v:
European Journal of Clinical Pharmacology
Purpose U.S. Food and Drug Administration (FDA) recommended telavancin dosing is based on total body weight (TBW) but lacks adjusted regimens for obese subjects with varying renal function. Our aim was to develop a physiologically based pharmacokinet
Autor:
Farzad Kobarfard, Mehran Kouchek, Seyedpouzhia Shojaei, Fatemeh Nezarat, Mohammad Sistanizad, Azadeh Ahmadi Koomleh, Sara Salarian, Elham Pourheidar, Mir Mohammad Miri, Shadi Ziaie, Rezvan Hassanpour
Publikováno v:
European Journal of Clinical Pharmacology
Purpose No study has been evaluated pharmacokinetic (PK) and pharmacodynamic (PD) properties of β-lactam antibiotics in patients with acute kidney injury (AKI), not requiring renal replacement therapy (RRT). We evaluated the time that plasma concent
Autor:
Hirotoshi Echizen, Tokujiro Uchida, Hirokuni Arai, Tomohiro Mizuno, Koshi Makita, Mizuho Asada, Shinichi Kijima, Masato Yasuhara, Hiromitsu Takahashi, Masashi Nagata
Publikováno v:
European Journal of Clinical Pharmacology. 77:735-745
The aims of the present study were to establish a population pharmacokinetic (PPK) model of cefazolin for adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and to assess the probability of target attainment (PTA) for the pro
Publikováno v:
European Journal of Clinical Pharmacology
Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. Howev
Publikováno v:
European Journal of Clinical Pharmacology
Purpose To analyze the clinical features and risk factors of tigecycline-associated hypofibrinogenaemia and study whether cefoperazone/sulbactam combined with tigecycline aggravates coagulopathy or hypofibrinogenaemia. Methods A retrospective case–
Publikováno v:
European Journal of Clinical Pharmacology
Purpose To evaluate the penetration of levofloxacin and dexamethasone sodium phosphate into the aqueous humour (AH) after administration in combination and as single molecules. Evaluation of the penetration of those agents in the site of action and t
Publikováno v:
European Journal of Clinical Pharmacology. 76:403-408
The purpose of this study was to compare therapeutic vancomycin trough levels in obese adults when using an original nomogram (phase I) versus a modified nomogram (phase II). This study compared a vancomycin nomogram with a modified vancomycin nomogr
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Ceftazidime–avibactam is a novel β-lactam/β-lactamase inhibitor combination recently approved in Europe and the USA for the treatment of adults with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), among other
Autor:
Qiang Li, Xiaoqing Liu, Wen-Ying Chen, Bijun Lv, Ling Sang, Pengpeng Li, Fenghua Liang, Lu Tan
Publikováno v:
European Journal of Clinical Pharmacology. 76:211-217
Therapeutic vancomycin levels are difficult to maintain in severe pneumonia patients who are receiving IV vancomycin therapy while on continuous venovenous hemofiltration (CVVH). The objective of this study was to determine the pharmacokinetics and m