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Autor:
David Raben, Jeltje Schulten, José Baselga, Jordi Giralt, J. Liu, Diana Bell, Kian K. Ang, David I. Rosenthal, Paul M. Harari, James A. Bonner, Sharon A. Spencer
Publikováno v:
European journal of cancer (Oxford, England : 1990)
Background Mucositis and dysphagia are common adverse effects of radiotherapy (RT) treatment of locally advanced squamous cell cancer of the head and neck (LA-SCCHN). Chemotherapy added to RT increases survival rates but causes worse mucositis and dy
Autor:
Sayako Matsushima, Nobuhiro Ueda, Kazuhiko Yamamoto, Miyako Kurihara, Ujjal K. Bhawal, Tadaaki Kirita, Hiroki Kuniyasu, Anja-Katrin Bosserhoff, Tomonori Sasahira
Publikováno v:
European journal of cancer (Oxford, England : 1990). 50(12)
Transport and Golgi organisation protein 1 (TANGO), also known as MIA3, belongs to the melanoma inhibitory activity (MIA) gene family. Although MIA acts as an oncogene, MIA2 and TANGO have a tumour-suppressive function in several malignancies; accord
Autor:
George S. Wilson, Paulina Gyllerup, Jan Åkervall, James H. Resau, Neal S. Goldstein, Katarina Lorenc, Jens Alm, Karolina Nilsson, Ylva Gårdinger, Chao Nan Qian, Sirisha R. Nandalur, Jacob Zhang, Bin Teh
Publikováno v:
European journal of cancer (Oxford, England : 1990). 50(3)
Global gene expression analysis was performed on pre-treatment biopsies from patients with squamous cell carcinoma of the head and neck (SCCHN) to discover biomarkers that can predict outcome of radiation based therapy.We initially evaluated RNA expr
Autor:
Anders Näsman, Nikolaos Tertipis, Lars Sivars, Torbjörn Ramqvist, Cecilia Nordfors, Linnea Haeggblom, Tina Dalianis, Linda Marklund, Andreas Ährlund-Richter, Tommy Nyberg, Nathalie Grün, Eva Munck-Wikland, Juan Du
Publikováno v:
European journal of cancer (Oxford, England : 1990). 49(11)
Patients with human papillomavirus (HPV) positive tonsillar and base of tongue squamous cell carcinoma (TSCC and BOTSCC, respectively) have a better clinical outcome than those with HPV negative tumours, irrespective of treatment. However, to better
Autor:
Jérôme Fayette, Rejnish Kumar, Martin Housset, Iman El-Hariry, Nigel Biswas-Baldwin, Philippe Legenne, Alain Berrier, Fernando Hurtado de Mendoza, Natalie Franklin, Natalie Compton, Kevin J. Harrington, Éva Remenár, Hisham Mehanna, Martin Robinson, M. Lau
Publikováno v:
European journal of cancer (Oxford, England : 1990). 49(7)
Background This randomised Phase II study assessed the activity and safety of concurrent chemoradiotherapy (CRT) and lapatinib followed by maintenance treatment in locally advanced, unresected stage III/IVA/IVB head and neck cancer. Patients and meth
Autor:
Holger Moch, Nicole Graf, Lena Züllig, Stephan K. Haerle, Sandro J. Stoeckli, Gerhard F. Huber, Matthias Roessle, Wolfram Jochum, Claudia Sandra Weber
Publikováno v:
European journal of cancer (Oxford, England : 1990). 49(8)
BACKGROUND: The transcription factor sex determining region Y (SRY)-box 2 (SOX2) (3q26.3-q27) has been recently identified as a recurrently activated major oncogene in squamous cell carcinoma of various sites. Its prognostic value in head and neck sq
Autor:
Michael Krimmel, Adelheid Munz, Martin Grimm, Sebastian Hoefert, Dorothea Alexander, Susanne Kluba, Juergen Hoffmann, Constanze Keutel, Siegmar Reinert, Joachim Polligkeit
Publikováno v:
European journal of cancer (Oxford, England : 1990). 48(17)
Introduction The vast majority of oral cancers are squamous cell carcinomas (OSCC). The effectiveness of adjuvant cytostatic chemotherapy for OSCC is frequently restricted due to an inducible cellular mechanism called multidrug resistance (MDR) and a
Autor:
Michelle Dean, Anthony M. Magliocco, Pinaki Bose, Steven C. Nakoneshny, Longlong Huang, Alexander C. Klimowicz, Shamir P. Chandarana, T. Wayne Matthews, Joseph C. Dort, Nigel T. Brockton
Publikováno v:
European journal of cancer (Oxford, England : 1990). 48(14)
Aim The prognostic significance of Ki67 expression in cancers, including oral squamous cell carcinoma (OSCC), is unclear. This may be partly attributed to the lack of consensus surrounding the optimal approach for measuring tumour Ki67 expression. Th
Autor:
Yuanzheng Qiu, Pingqing Tan, Yongquan Tian, Xin Zhang, Cong-Liang Xie, Donghai Huang, Yong Liu, Lin Qi, Guoqing Hu, Xiaojuan Zhou
Publikováno v:
European journal of cancer (Oxford, England : 1990). 46(16)
HMGB1 overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in squamous-cell carcinoma of the head and neck (SCCHN) remains unclear. The aim of the present investigation was to analyse HMGB1 protein expression in
Autor:
Miyako Kurihara, Tadaaki Kirita, Ujjal K. Bhawal, Anja-Katrin Bosserhoff, Tomonori Sasahira, Kazuhiko Yamamoto, Hiroki Kuniyasu
Publikováno v:
European journal of cancer (Oxford, England : 1990). 46(12)
We examined the role of angiogenesis/lymphangiogenesis and the relationship between melanoma inhibitory activity (MIA) and angiogenesis or lymphangiogenesis in oral squamous cell carcinoma (OSCC). One hundred and one formalin-fixed, paraffin-embedded