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Autor:
Kan Ito, Toshihide Ueno, Daisuke Matsubara, Yoshinao Oda, Shintaro Iwata, Hiroaki Hiraga, Teruya Kawamoto, Norifumi Naka, Masachika Ikegami, Shinji Kohsaka, Hiroshi Kobayashi, Koichi Ogura, Yoshiyuki Suehara, Tsukasa Yonemoto, Toru Motoi, Hiroyuki Mano, Tomotake Okuma, Makoto Hirata, Koichi Matsuda, Tomohisa Sakai, Yoshihiro Nishida, Akira Kawai, Shinya Kojima
Publikováno v:
European journal of cancer (Oxford, England : 1990). 145
Previous studies have not clearly identified a prognostic factor for desmoid tumours (DT). Whole-exome sequencing (WES) and/or RNA sequencing (RNA-seq) were performed in 64 cases of DT to investigate the molecular profiles in combination with the cli
Autor:
C. Goessl, Nadine Tung, Suzette Delaloge, Wendy Bannister, Elżbieta Senkus, Binghe Xu, Arnold Degboe, Pierfranco Conte, Norikazu Masuda, Robert Hettle, Seock Ah Im, Kathryn J. Ruddy, Susan M. Domchek, Anne C Armstrong, Wei Li, Mark E. Robson
Publikováno v:
Eur J Cancer
Background The phase III OlympiAD study (NCT02000622) showed a statistically significant progression-free survival benefit with olaparib versus chemotherapy treatment of physician's choice (TPC) in patients with a germline BRCA mutation and human epi
Autor:
Rony Kapoor, Richard A. Scolyer, R Max Conway, Annabel Goodwin, Phoebe Star, Pascale Guitera, Georgina V. Long
Publikováno v:
European journal of cancer (Oxford, England : 1990). 92
The germline BAP1 (BRCA1-associated protein-1) mutation and associated cancer pre-disposition syndrome was first described in 2011. Since then, physicians have considered this diagnosis for patients with a characteristic personal or family history of
Autor:
Jean-Marie Michot, Christophe Fermé, David Ghez, Sandrine Aspeslagh, Julien Lazarovici, Amélie Bigorgne, Alina Danu, Vincent Ribrag, Aurélien Marabelle
Publikováno v:
European journal of cancer (Oxford, England : 1990). 85
Hodgkin lymphoma (HL) was one of the first few cancers to be cured first with radiotherapy alone and then with a combination of chemotherapy and radiotherapy. Around 80% of the patients with HL will be cured by first-line therapy. However, the ionisi
Autor:
Guido Kobbe, Ellen Wollmer, A Finck, Markus Ditschkowski, Nadezda Basara, Andreas Neubauer, Martin F. Fey, Peter Dreger, Sebastian Scholl, Helmut R. Salih, Ralf G. Meyer, Michael Lübbert, Jürgen Finke, Andreas Burchert, S K Metzelder, Thomas Pabst, Tobias Schroeder, Katharina Götze, Aristoteles Giagounidis
Publikováno v:
European journal of cancer (Oxford, England : 1990). 86
Background Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)–positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. FLT3-ITD ki
Autor:
Armelle Delahaye, Françoise Borson Chazot, Christelle De La Fouchardiere, Jonathan Lopez, Myriam Decaussin-Petrucci, Jean-Louis Peix, Jean-Christophe Lifante, Sandrine Masson, Julien Berthiller, Anne-Laure Giraudet, Françoise Descotes, Claire Bournaud-Salinas
Publikováno v:
European journal of cancer (Oxford, England : 1990). 92
Background The prognosis of poorly differentiated thyroid carcinomas (PDTC) is heterogeneous though generally poor. The objectives of this study were to identify clinical and molecular factors of poor prognosis. Methods One hundred four consecutive p
Publikováno v:
European journal of cancer (Oxford, England : 1990). 78
Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiologi
Autor:
Agnieszka Wozniak, Herman Burger, Axelle Nzokirantevye, Erik A.C. Wiemer, Marcel Smid, Raf Sciot, Patrick Schöffski, Stefan Sleijfer, Giuseppe Floris
Publikováno v:
European Journal of Cancer, 75, 33-40. Elsevier Ltd.
Background Recent phase II and III clinical trials demonstrated anti-tumour activity of eribulin, a tubulin-interacting cytotoxic agent, in patients with metastatic soft tissue sarcoma (STS). In this exploratory study, we aimed to identify putative m
Autor:
Luisa Lorenzi, Claudio Agostinelli, Soo Jeong Portscher-Kim, Martin-Leo Hansmann, Holger Hackstein, Claudia Döring, Silvia Lonardi, Jay Mehta, Sylvia Hartmann, José Cabeçadas, Stefano Pileri, Fabio Facchetti, Stefan Kippenberger, Daniel Martinez, Ingrid Simonitsch-Klupp, Elias Campo, Anita Borges, Fabio Fuligni, Pier Paolo Piccaluga
Publikováno v:
European journal of cancer (Oxford, England : 1990). 64
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20% of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been
Publikováno v:
European journal of cancer (Oxford, England : 1990). 56
Background Diagnosis of leptomeningeal metastasis (LM) has become increasingly common because of enhanced detection via routine use of magnetic resonance imaging (MRI) and longer survival of patients by better systemic control. We investigated clinic