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Publikováno v:
Epilepsy Research. 154:144-148
Objectives Valproate (VPA) is one of the most frequently used anti-epileptic drugs (AEDs) worldwide. Its effects in decreasing the retinal nerve fibre layer (RNFL) thickness remain debatable. We aimed to evaluate the effect of VPA usage on the RNFL i
Autor:
Meiping Ding, Yi Guo, Chun-Hong Shen, Sha Xu, Yin Hu, Yao Ding, Yin-Xi Zhang, Fan Yang, Shen-Qiang Yan, Yang Zheng
Publikováno v:
Epilepsy Research. 154:21-25
Purpose The potential of microRNAs (miRNAs) as biomarkers has been explored in various brain diseases, including epilepsy. In this study, we are aiming to analyze the aberrant expression of miRNA-145-5p in patients with refractory epilepsy, and to fu
Autor:
Steve Chung, Aashit Shah, JungAh Jung, John M. Stern, Saurabh R. Sinha, David Blum, Hailong Cheng, Todd Grinnell
Publikováno v:
Epilepsy Research. 153:59-65
Objective To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS). Methods Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monothera
Autor:
Khadija Rantell, Rebecca A. Pope, Mary-Anne Wright, J Foong, Pamela J. Thompson, Jason Stretton
Publikováno v:
Epilepsy Research. 152:59-66
Objective Predictors of psychiatric outcome following TLE surgery have proved elusive and represent a current challenge in the practice of TLE surgery. This prospective study investigated whether frontal lobe dysfunction is predictive of poorer psych
Publikováno v:
Epilepsy Research. 152:42-51
Recognition of insular epilepsy may sometimes be challenging due to the rapid speed at which insular seizures can spread throughout the cortex via extensive connections to surrounding cortices. The spectrum weighted adaptive directed transfer functio
Publikováno v:
Epilepsy Research. 150:66-69
We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one indiv
Publikováno v:
Epilepsy Research. 149:9-12
Publikováno v:
Epilepsy Research. 149:83-87
Introduction Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not bee
Publikováno v:
Epilepsy Research. 149:13-16
A combined adult and pediatric population pharmacokinetic model including covariate effects was developed; simulations were subsequently performed to guide intravenous pediatric dosing adaptations. Two pharmacokinetic trials with sparse blood samplin
Publikováno v:
Epilepsy Research. 148:90-95
Objective We report the frequency of seizure, its possible mechanisms and effect of seizure on the outcome of tuberculous meningitis (TBM). Methods Seventy-nine patients with TBM admitted during 2014–2017 were evaluated. The seizures were categoriz