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pro vyhledávání: ''
Autor:
Lauren A. Skirvin, Elizabeth A. Thiele, Reid A. Grinspoon, Bradley M. Fleming, Sandip Patel, Christina Wade, Emma Wolper, Patricia L. Bruno
Publikováno v:
Epilepsia. 62:1594-1603
OBJECTIVE Cannabidiol (CBD) has been shown to reduce seizures among patients with refractory epilepsies of various etiologies in recent clinical trials and an expanded access program (EAP). Most studies report efficacy over short time periods (
Autor:
Ara Ko, Joon Soo Lee, Se Hee Kim, Jong Rak Choi, Han Som Choi, Seung-Tae Lee, Hoon Chul Kang, Heung Dong Kim
Publikováno v:
Epilepsia. 62:1656-1664
Objective It has been known that West syndrome (WS) patients with an unknown etiology have better clinical outcomes than patients with an identified etiology of any kind. However, after the exponential discovery of genes with mutations responsible fo
Autor:
Victor Biton, Enrique Carrazana, Adrian L. Rabinowicz, Eric Segal, R. Edward Hogan, David F. Cook, Daniel Tarquinio, Blanca Vazquez, Ian Miller, Kore Liow, Michael R. Sperling, Gregory D. Cascino, James W. Wheless, Dennis J. Dlugos, Jay Desai
Publikováno v:
Epilepsia
Objective Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration.
Autor:
J. Helen Cross, Matthew Wong, Daniel Checketts, Hari Bhathal, Elaine C. Wirrell, Maria Mazurkiewicz-Bełdzińska, Kevan E. VanLandingham, Michael Privitera, Eric D. Marsh, Volker Knappertz, Vicente Villanueva
Publikováno v:
Epilepsia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Objective To estimate time to onset of cannabidiol (CBD) treatment effect (seizure reduction and adverse events [AEs]), we conducted post hoc analyses of data from two randomized, placebo-controlled, Phase 3 trials, GWPCARE3 (NCT02224560) and GWPCARE
Autor:
Cecilie Johannessen Landmark, Heidrun Potschka, Elaine C. Wirrell, Jo M. Wilmshurst, Svein I. Johannessen, Stéphane Auvin, Dorothée G.A. Kasteleijn-Nolst Trenité
Publikováno v:
Epilepsia
Developmental and epileptic encephalopathies (DEEs) are among the most chal- lenging of all epilepsies to manage, given the exceedingly frequent and often severe seizure types, pharmacoresistance to conventional antiseizure medications, and nu- merou
Autor:
Anastasia Zekeridou, Chandana Devi Kattala, Scott K. Dessain, Howard S. Fox, Olga Taraschenko, Fetweh H. Al-Saleem, George P. Casale, Fnu Farukhuddin, Sean J. Pittock, Raymond Dingledine, Gregory Willcockson, Ember Eldridge
Publikováno v:
Epilepsia
Objective Neuroinflammation associated with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may facilitate seizures. We previously showed that intraventricular administration of cerebrospinal fluid from patients with anti-NMDAR encephalitis t
Autor:
Terence J. O'Brien, Eliza Honybun, Janet E. Graham, Genevieve Rayner, Alison A. Hitchcock, Alison Anderson, Piero Perucca, Charles B Malpas, Rebecca Thwaites, Frank J.E. Vajda
Publikováno v:
Epilepsia. 62:709-719
Objective Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD).
Publikováno v:
Epilepsia
Seizure clusters must be treated quickly and effectively to prevent progression to prolonged seizures and status epilepticus. Rescue therapy for seizure clusters has focused on the use of benzodiazepines. Although intravenous benzodiazepine administr
Autor:
Sarah A Steimel, Bradley C. Lega, Edward J. Camp, Stephen Meisenhelter, Michael R. Sperling, Richard Adamovich-Zeitlin, Markus E. Testorf, Michael J. Kahana, Robert E. Gross, Barbara C. Jobst, Yinchen Song, Robert J. Quon, Todd MacKenzie
Publikováno v:
Epilepsia
OBJECTIVE This study was undertaken to evaluate the influence that subject-specific factors have on intracranial interictal epileptiform discharge (IED) rates in persons with refractory epilepsy. METHODS One hundred fifty subjects with intracranial e
Publikováno v:
Epilepsia. 62:250-257
Objective Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This stu