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pro vyhledávání: '"59"'
Autor:
Frederic deBock, Alexis Fayd'herbe de Maudave, Chaitali Ghosh, Federica Bertaso, Julie Espallergues, Alexandre Milman, Leonie Runtz, Marion Toussenot, Benoit Girard, Nathalie C. Guérineau, Nicola Marchi, Jean-Marc Pascussi
Publikováno v:
Epilepsia
Epilepsia, Wiley, 2018, 59 (1), pp.123-134. ⟨10.1111/epi.13942⟩
Epilepsia, Wiley, 2018, 59 (1), pp.123-134. ⟨10.1111/epi.13942⟩
OBJECTIVE Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask wh
Publikováno v:
Epilepsia. 43:3-8
Summary: Purpose: The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absenc