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Autor:
Christopher Carlsten, Maria J. Aristizabal, Michael S. Kobor, Christopher F. Rider, Sarah M. Merrill, Amy M. Inkster, Chaini Konwar, J.L. MacIsaac, Gian Luca Negri, Rebecca Asiimwe
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-18 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are more likely to acquire SARS-CoV-
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttranslational modification by different enzymes
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-11 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the p
Autor:
Richard Cheng-An Chang, Kara N. Thomas, Michael C. Golding, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-16 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural changes that are part of a nuc
Autor:
Viviana Barra, Xena Giada Pappalardo
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-21 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin formation and gene silencing. It has a fundamental role in preserving genome stability (including chromosome stability) by controlling both gene expression and chr
Autor:
Chuanjin Yu, Xianfu Yi, Yicong Meng, Guo-Lian Ding, Yiran Zhao, Yinyu Wang, Xin-Mei Liu, Yiting Mao, He-Feng Huang, Jian-Zhong Sheng
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-13 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Maternal protein restriction diet (PRD) increases the risk of metabolic dysfunction in adulthood, the mechanisms during the early life of offspring are still poorly understood. Apart from genetic factors, epigenetic mechanisms are crucial
Autor:
Maria E. Lopatkina, Maria I. Yablonskaya, Emil Valeev, Nadezhda V. Shilova, Veniamin S. Fishman, M.M. Gridina, Zhanna G. Markova, I. N. Lebedev, Viktoria Yu Voinova, Ludmila P. Nazarenko, Evgeniy A. Mozheiko
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which results in nonuniform genomic co
Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-12 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
BackgroundThe mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vitamin D on DNA methylation and DN
Autor:
Fei Li, Wei Chen, Stefan Kempa, Haijin He, Hyoju Ban, Qingsong Gao, Martina Weigt, Guido Mastrobuoni
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-13 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood. In this study, we identified a fission yeast homologue of human spl
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-14 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheritance is mediated through epig