Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Christian Gaiddon"'
Publikováno v:
Endocrinology. 136:4331-4338
Somatic mutations of the alpha-subunit of Gs (Gs alpha) have been detected previously at high frequency in human PRL- and/or GH-producing pituitary tumors. To test whether these mutants are responsible for the increased production of these hormones,
Publikováno v:
Endocrinology. 137(4)
Constitutively active mutations of the G protein alpha(S) subunit are detected at a high frequency in human pituitary adenomas that secrete GH or PRL. It seems possible that over-expression of the pituitary cell-specific transcription factor Pit-1/GH