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Publikováno v:
Endocrinology. 128:2041-2044
Previous data from this laboratory revealed a rapid and unexpectedly long inhibition of pituitary gonadotropin secretion in ovariectomized monkeys after a single high dose injection of the GnRH antagonist antide. This extended action of antide may co
Publikováno v:
Endocrinology. 126:2499-2505
The mechanism by which gamma-aminobutyric acid (GABA) stimulates the release of LH was analyzed in cultured female rat pituitary cells. In 3-h incubations, GABA (1-100 microM) caused a dose-dependent increase in LH release, with the maximal response
Publikováno v:
Endocrinology. 137(2)
Female rats were treated with phenobarbital, dexamethasone, 3-methylcholanthrene, clofibrate, or isoniazid to induce different hepatic cytochromes P-450. The profile of hydroxylated metabolites of estradiol (E2) formed by liver microsomes was then de
Autor:
Sonya Conway, Samuel Speciale, Helena J. Mauceri, Lorrie Richardson, L. Krulich, Robin Moherek
Publikováno v:
Endocrinology. 126(2)
Both alpha 2-adrenergic (alpha 2) and serotonergic (5HT) neurons are associated with stimulation of GH secretion via GRH release. The object of this study was to determine whether the 5HT system is involved in the stimulation of GH secretion by alpha
Autor:
Carlos Libertun, Damasia Becu
Publikováno v:
Endocrinology. 113:1980-1984
Pharmacological manipulation of H1 and H2 histamine receptors clearly indicates their participation in control of anterior pituitary secretion by the brain. Of particular interest is the PRL-releasing effect of H2 histamine receptor blocking agents l
Publikováno v:
Endocrinology. 113:687-692
The goal of these experiments was to determine if isoproterenol-stimulated renin secretion in the rat is mediated by activation of beta 1- and/or beta 2-adrenoceptors. The rat renal cortical slice preparation was used. The renin secretory rate was a
Publikováno v:
Endocrinology. 116:2044-2048
p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or
Publikováno v:
Endocrinology. 112:315-320
The effects of prior exposure of normal rat adrenocortical cells to ACTH on the responsiveness of the cells to subsequent stimulation with the hormone have been studied. ACTH induces a time- and concentration-dependent refractoriness of both cAMP for
Further Evidence That Serotonin Is a Neurotransmitter Involved in the Control of Prolactin Secretion
Publikováno v:
Endocrinology. 100:692-698
Administration of a new specific serotonin uptake inhibitor, fluoxetine, depressed the firing rate of raphe neurons. A highly significant increase in serum prolactin levels was observed after ip injection of 30 mg/kg of 5-hydroxytryptophan (5-HTP) in
Publikováno v:
Endocrinology. 115:858-861
beta-Adrenergic antagonists provide moderate symptomatic relief for most hyperthyroid patients, although these agents have no direct antithyroid effects. Propranolol administration results in modest declines in serum T3 concentrations in both hyperth