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Publikováno v:
Endocrine-Related Cancer. 23:1-19
Adrenocortical carcinoma (ACC) generally has poor prognosis. Existing treatments provide limited benefit for most patients with locally advanced or metastatic tumors. We investigated the mechanisms for the cytotoxicity, xenograft suppression, and adr
Autor:
M Christine Bruce, Steven Weger, Pratima Basak, Afshin Raouf, Leigh C. Murphy, Sumanta Chatterjee
Publikováno v:
Endocrine-Related Cancer
Although the role of estrogen signaling in breast cancer development has been extensively studied, the mechanisms that regulate the indispensable role of estrogen in normal mammary gland development have not been well studied. Because of the unavaila
Publikováno v:
Endocrine-Related Cancer. 17:335-349
The gonadotropin hypothesis proposes that elevated serum gonadotropin levels may increase the risk of epithelial ovarian cancer (EOC). We have studied the effect of treating EOC cell lines (OV207 and OVCAR-3) with FSH or LH. Both gonadotropins activa
Autor:
Harald Enzmann, Ashish Shukla, Jean Grisouard, Alexander Hermani, Doris Mayer, Volker Ehemann
Publikováno v:
Endocrine-Related Cancer. 16:429-441
Insulin and insulin analogs stimulate proliferation of human mammary epithelial cells. We identified and analyzed the signaling pathways related to cell proliferation induced by regular insulin and by four insulin analogs presently approved for thera
Autor:
Teresa K. Woodruff, Joanna E. Burdette
Publikováno v:
Endocrine-Related Cancer. 14:679-689
Activin is a member of the transforming growth factor β superfamily that regulates mammary cell function during development, lactation, and in cancer. Activin slows the growth of breast cancer cells by inducing G0/G1 cell cycle arrest. Estrogen is a
Publikováno v:
Endocrine-Related Cancer. 14:325-335
Sphingosine kinases (SK) catalyze the formation of sphingosine-1-phosphate (S1P) which plays a crucial role in cell growth and survival. Here, we show that prolactin (PRL) biphasically activates the SK-1, but not the SK-2 subtype, in the breast adeno
Autor:
R K Hansen, M J Bissell
Publikováno v:
Endocrine-related cancer. :95-113
The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the com
Publikováno v:
Endocrine-related cancer. 20(3)
Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control c
Autor:
Susanne Roelle, Thomas Gudermann
Publikováno v:
Endocrine-related cancer. 13(4)
Approximately 15–25% of all primary cancers of the lung are classified histologically as small cell lung carcinoma (SCLC), a subtype characterized by rapid growth and a poor prognosis. Neuropeptide hormones like bombesin/gastrin-releasing peptide,
Autor:
J. Lawrence, Wei Yue, Richard J. Santen, Masamura A, Berstein L, Zhang Z, Rakesh Kumar, Robert X.-D. Song, Jeng Mh
Publikováno v:
Endocrine-related cancer. 12
Deprivation of estrogen causes breast tumors in women to adapt and develop enhanced sensitivity to this steroid. Accordingly, women relapsing after treatment with oophorectomy, which substantially lowers estradiol for a prolonged period, respond seco