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Autor:
Junko Akaishi, Naoki Oishi, Toru Odate, Koichi Ito, Masataka Kawai, Ryohei Katoh, Ippei Tahara, Kunio Mochizuki, Tetsuo Kondo
Publikováno v:
Endocrine Pathology
Most anaplastic thyroid carcinomas (ATCs) arise from papillary thyroid carcinoma (PTC). This process is also called anaplastic transformation, and the morphological harbingers of this phenomenon in nodal recurrence have not been assessed systematical
Autor:
Tetsuo Kondo, Naoki Oishi, Kunio Mochizuki, Ippei Tahara, Ryohei Katoh, Toshio Oyama, Kazuyuki Miyata, Akira Miyauchi, Mitsuyoshi Hirokawa
Publikováno v:
Endocrine Pathology. 31:274-282
Intrathyroid thymic carcinoma (ITTC) is a rare malignant neoplasm considered to be a eutopic thymic carcinoma (TC) arising ectopically in the thyroid. Histopathologically, ITTC resembles squamous cell carcinoma of the thymus with positive TC markers
Autor:
Ricardo V. Lloyd, Heather Hardin, Vishal Chanana, Rakesh Mandal, Jason N. Rosenbaum, Darya Buehler, Damodaran Narayanan, Michael Schwalbe
Publikováno v:
Endocrine Pathology. 31:254-263
Pulmonary neuroendocrine neoplasms (NENs) are classified into low-grade neuroendocrine tumors and high-grade neuroendocrine carcinomas (NECs). There are significant differences in therapeutic strategies of the different NEN subtypes, and therefore, p
Publikováno v:
Endocrine Pathology. 31:166-173
The underlying mechanisms of aggressive pituitary neuroendocrine tumors (pitNETs) are still unclear. The p16 protein, encoded by the CDKN2A tumor suppressor gene on chromosome 9p21, is commonly reported to be lost in numerous types of cancer. For thi
Publikováno v:
Endocrine Pathology. 30:262-269
Long non-coding RNAs (lncRNAs) participate in transcription and in epigenetic or post-transcriptional regulation of gene expression. They also have roles in epithelial to mesenchymal transition and in carcinogenesis. Because lncRNAs may also have a r
Publikováno v:
Endocrine Pathology. 30:305-311
A variety of epigenetic dysregulations are observed in thyroid malignancies. EZH2, the catalytic subunit of polycomb repressive complex 2, is upregulated in advanced thyroid cancers. EZH2 can catalyze trimethylation of histone H3 at lysine 27 (H3K27m
Publikováno v:
Endocrine Pathology. 30:56-63
Recent studies suggest onco-regulatory roles for two long non-coding RNAs (lncRNAs), MALAT1 and HOTAIR, in various malignancies; however, these lncRNAs have not been previously examined in neuroendocrine neoplasms (NENs) of gastroenteropancreatic ori
Autor:
Divya Sahu, Sounak Gupta, Prabin Thapa, Stephen A. Boorjian, John S. Bomalaski, John C. Cheville, Donna E. Hansel, Igor Frank
Publikováno v:
Endocrine Pathology. 29:236-241
High-grade neuroendocrine carcinomas (HGNECs) of the urinary bladder encompass small cell (SCNEC) and large cell neuroendocrine carcinomas (LCNEC). Currently, recommended initial management is with systemic chemotherapy, followed by consolidative the
Publikováno v:
Endocrine Pathology. 28:159-164
Methods of diagnosing malignant pheochromocytoma (PCC) or paraganglioma (PGL) are needed. However, there are no reliable histopathologic criteria to distinguish malignant PCC/PGLs. The recent genomic analysis of The Cancer Genome Atlas (TCGA) provide
Autor:
Zubair W. Baloch, Virginia A. LiVolsi, Kathleen T. Montone, Shuanzeng Wei, Jennifer J.D. Morrissette
Publikováno v:
Endocrine Pathology. 27:359-362
Medullary thyroid carcinoma (MTC) harbors rearranged during transfection (RET) gene and rarely RAS gene mutations. The knowledge of the type of gene mutation in MTC is important to determine the treatment of the patients and the management of their f