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Autor:
David Llobet-Navas, Jose M. Silva, Partha Mukhopadhyay, Meredith L Davis, Rachel L Werner, Laura Devis-Jauregui, Erin A. Nekritz, Koon-Kiu Yan, Ruth Rodriguez-Barrueco, Jiyang Yu
Publikováno v:
EMBO Rep
During the female lifetime, the expansion of the epithelium dictated by the ovarian cycles is supported by a transient increase in the mammary epithelial stem cell population (MaSCs). Notably, activation of Wnt/β-catenin signaling is an important tr
Autor:
Matylda Macias, Małgorzata Alicja Śliwińska, Agnieszka Chacinska, Michal Turek, Natalia Nowak, Konrad Kowalski, Nilesh Shanmugam, Katarzyna Banasiak, Malgorzata Piechota, Marta Niklewicz, Wojciech Pokrzywa
Publikováno v:
EMBO Reports
EMBO Rep
EMBO Rep
Organismal functionality and reproduction depend on metabolic rewiring and balanced energy resources. However, the crosstalk between organismal homeostasis and fecundity and the associated paracrine signaling mechanisms are still poorly understood. U
Autor:
Maria Gomez, Edmund C. Jenkins, Nagma Shah, Gabriella Casalena, Timothy C. Kenny, Dazhi Zhao, Giovanni Manfredi, Sara R. Guariglia, Doris Germain
Publikováno v:
EMBO Reports
Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex‐ and tissue‐specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male an
Autor:
Masaya Miyamoto, Tetsu Akiyama, Yoshihiro Kawasaki, Sakiko Suda, Katsuhiko Shirahige, Ryuichiro Nakato, Naoko Yokota, Kosuke Matsumura, Takeaki Oda, Lumi Negishi
Publikováno v:
EMBO Rep
Long non‐coding RNAs (lncRNAs) are aberrantly expressed in many disease conditions, including cancer. Accumulating evidence indicates that some lncRNAs may play critical roles in cancer progression and metastasis. Here, we identify a set of lncRNAs
Publikováno v:
EMBO Rep
In Drosophila melanogaster males, X-chromosome monosomy is compensated by chromosome-wide transcription activation. We found that complete dosage compensation during embryogenesis takes surprisingly long and is incomplete even after 10 h of developme
Autor:
Michael J. Smanski, David Zarkower
Publikováno v:
EMBO Rep
Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non‐genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstr
Publikováno v:
EMBO Reports
The spatial and temporal dynamics of cell contractility plays a key role in tissue morphogenesis, wound healing, and cancer invasion. Here, we report a simple optochemical method to induce cell contractions in vivo during Drosophila morphogenesis at
Publikováno v:
EMBO Rep
Female sterile (1) Yb (Yb) is a primary component of Yb bodies, perinuclear foci considered to be the site of PIWI-interacting RNA (piRNA) biogenesis in Drosophila ovarian somatic cells (OSCs). Yb consists of three domains: Helicase C-terminal (Hel-C