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pro vyhledávání: ''
Autor:
Caiqian Wang, Yuanyuan Geng, Haoran Wang, Zeheng Ren, Qingxiu Hou, An Fang, Qiong Wu, Liqin Wu, Xiujuan Shi, Ming Zhou, Zhen F Fu, Jonathan F Lovell, Honglin Jin, Ling Zhao
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1451-1483 (2024)
Abstract Although protein subunit vaccines generally have acceptable safety profiles with precise antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular immunity and the need for vaccine adjuvants and delivery syste
Externí odkaz:
https://doaj.org/article/a34d3dfc3d324d818a21353b94f3adc5
Autor:
Darren ZL Mok, Danny JH Tng, Jia Xin Yee, Valerie SY Chew, Christine YL Tham, Justin SG Ooi, Hwee Cheng Tan, Summer L Zhang, Lowell Z Lin, Wy Ching Ng, Lavanya Lakshmi Jeeva, Ramya Murugayee, Kelvin K-K Goh, Tze-Peng Lim, Liang Cui, Yin Bun Cheung, Eugenia Z Ong, Kuan Rong Chan, Eng Eong Ooi, Jenny G Low
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1310-1323 (2024)
Abstract Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have identified correlates of vaccine immunogenicity that could be useful to guide developmen
Externí odkaz:
https://doaj.org/article/90c7121c4d0546eb8018f9ef0e765fd0
Autor:
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1324-1351 (2024)
Abstract Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild-type p53 protein is implicated in ccRCC therapy re
Externí odkaz:
https://doaj.org/article/943d98c6d7a140ae919de5ddf5a741fd
Autor:
Laura Poupon-Bejuit, Amy Geard, Nathan Millicheap, Eridan Rocha-Ferreira, Henrik Hagberg, Claire Thornton, Ahad A Rahim
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1284-1309 (2024)
Abstract Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Pe
Externí odkaz:
https://doaj.org/article/755beec1f79d489494da254d818c003f
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
Autor:
Mami Matsumoto, Katsuyoshi Matsushita, Masaya Hane, Chentao Wen, Chihiro Kurematsu, Haruko Ota, Huy Bang Nguyen, Truc Quynh Thai, Vicente Herranz-Pérez, Masato Sawada, Koichi Fujimoto, José Manuel García-Verdugo, Koutarou D Kimura, Tatsunori Seki, Chihiro Sato, Nobuhiko Ohno, Kazunobu Sawamoto
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1228-1253 (2024)
Abstract In the injured brain, new neurons produced from endogenous neural stem cells form chains and migrate to injured areas and contribute to the regeneration of lost neurons. However, this endogenous regenerative capacity of the brain has not yet
Externí odkaz:
https://doaj.org/article/38a75c2192bc4cdea63491e9304280eb
Autor:
Nneka Southwell, Onorina Manzo, Sandra Bacman, Dazhi Zhao, Nicole M Sayles, Jalia Dash, Keigo Fujita, Marilena D’Aurelio, Annarita Di Lorenzo, Giovanni Manfredi, Hibiki Kawamata
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1352-1378 (2024)
Abstract Mutations in CHCHD10, a mitochondrial protein with undefined functions, are associated with autosomal dominant mitochondrial diseases. Chchd10 knock-in mice harboring a heterozygous S55L mutation (equivalent to human pathogenic S59L) develop
Externí odkaz:
https://doaj.org/article/06da78e884b74bbabfb6411ca3018288
Autor:
Satya Ranjan Sahu, Abinash Dutta, Doureradjou Peroumal, Premlata Kumari, Bhabasha Gyanadeep Utakalaja, Shraddheya Kumar Patel, Narottam Acharya
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1254-1283 (2024)
Abstract Disseminated fungal infections account for ~1.5 million deaths per year worldwide, and mortality may increase further due to a rise in the number of immunocompromised individuals and drug-resistance fungal species. Since an approved antifung
Externí odkaz:
https://doaj.org/article/b93bc1c0f9664b2b9dc23a43d020d6e8
Autor:
Jemima Becker, Francis Szele
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1223-1225 (2024)
A new paper published in EMBO Molecular Medicine, Matsumoto et al (2024), elegantly shows that polysialic acid (PSA), has a new function—inhibition of migration. Molecular control over cell migration during brain development is essential for proper
Externí odkaz:
https://doaj.org/article/ff2ba9f05c434fdfac089ba439cfef5f
Autor:
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana SH Costa, Antonio Esposito, Angelo D’Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1379-1403 (2024)
Abstract Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the e
Externí odkaz:
https://doaj.org/article/85f00a3b22fa420a87b07c2ca8140bde
Autor:
Yao Xiang, Jorge Mata-Garrido, Yuanji Fu, Christophe Desterke, Eric Batsché, Ahmed Hamaï, Christine Sedlik, Youssouf Sereme, David Skurnik, Abdelali Jalil, Rachel Onifarasoaniaina, Eric Frapy, Jean-Christophe Beche, Razack Alao, Eliane Piaggio, Laurence Arbibe, Yunhua Chang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1404-1426 (2024)
Abstract As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis and colorectal cancer (CRC). Here, we demonstrated that the epigenetic regulator,
Externí odkaz:
https://doaj.org/article/de2e44b1297c4b6381469b61856d34e2