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Autor:
Liping Ye, Chuyong Lin, Xi Wang, Qiji Li, Yue Li, Meng Wang, Zekun Zhao, Xianqiu Wu, Dongni Shi, Yunyun Xiao, Liangliang Ren, Yunting Jian, Meisongzhu Yang, Ruizhang Ou, Guangzheng Deng, Ying Ouyang, Xiangfu Chen, Jun Li, Libing Song
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
Abstract Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant mechanism of tamoxifen resistance, the reason for ERα decrease during tamoxifen
Externí odkaz:
https://doaj.org/article/9d1e2d7aba0149b99b9ad9389ece5549
Autor:
Abir Arfaoui, Claire Rioualen, Violette Azzoni, Guillaume Pinna, Pascal Finetti, Julien Wicinski, Emmanuelle Josselin, Manon Macario, Rémy Castellano, Candi Léonard‐Stumpf, Anthony Bal, Abigaelle Gros, Sylvain Lossy, Maher Kharrat, Yves Collette, Francois Bertucci, Daniel Birnbaum, Hayet Douik, Ghislain Bidaut, Emmanuelle Charafe‐Jauffret, Christophe Ginestier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic tar
Externí odkaz:
https://doaj.org/article/c9002abaa4bb472dafea9936d6b75e8c
Autor:
Eric Raspé, Katia Coulonval, Jaime M Pita, Sabine Paternot, Françoise Rothé, Laure Twyffels, Sylvain Brohée, Ligia Craciun, Denis Larsimont, Véronique Kruys, Flavienne Sandras, Isabelle Salmon, Steven Van Laere, Martine Piccart, Michail Ignatiadis, Christos Sotiriou, Pierre P Roger
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1052-1066 (2017)
Abstract Cyclin D‐CDK4/6 are the first CDK complexes to be activated in the G1 phase in response to oncogenic pathways. The specific CDK4/6 inhibitor PD0332991 (palbociclib) was recently approved by the FDA and EMA for treatment of advanced ER‐po
Externí odkaz:
https://doaj.org/article/9b2d45e7df5c4aa580875b12ef3ec949
Autor:
Aldema Sas‐Chen, Miriam R Aure, Limor Leibovich, Silvia Carvalho, Yehoshua Enuka, Cindy Körner, Maria Polycarpou‐Schwarz, Sara Lavi, Nava Nevo, Yuri Kuznetsov, Justin Yuan, Francisco Azuaje, Oslo Breast Cancer Research Consortium (OSBREAC), Igor Ulitsky, Sven Diederichs, Stefan Wiemann, Zohar Yakhini, Vessela N Kristensen, Anne‐Lise Børresen‐Dale, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1052-1064 (2016)
Abstract Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal‐like subtype
Externí odkaz:
https://doaj.org/article/4f7cfb1585b94dd5ac5eed26ab401081
Autor:
Murugan Kalimutho, Debottam Sinha, Jessie Jeffery, Katia Nones, Sriganesh Srihari, Winnie C Fernando, Pascal HG Duijf, Claire Vennin, Prahlad Raninga, Devathri Nanayakkara, Deepak Mittal, Jodi M Saunus, Sunil R Lakhani, J Alejandro López, Kevin J Spring, Paul Timpson, Brian Gabrielli, Nicola Waddell, Kum Kum Khanna
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
Abstract The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showe
Externí odkaz:
https://doaj.org/article/81a0772c1ea5410bbe8b8145afcfbc3d
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