Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Preclinical research"'
Publikováno v:
eLife, Vol 10 (2021)
The Reproducibility Project: Cancer Biology (RPCB) was established to provide evidence about reproducibility in basic and preclinical cancer research, and to identify the factors that influence reproducibility more generally. In this commentary we ad
Externí odkaz:
https://doaj.org/article/cf46824b5e994a08a988e72e11f468d5
Publikováno v:
eLife, Vol 10 (2021)
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of
Externí odkaz:
https://doaj.org/article/1e36a8928c5749cab5a929648e5df906
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of
Autor:
Alex John London, Jonathan Kimmelman
Publikováno v:
eLife, Vol 4 (2015)
The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and d
Externí odkaz:
https://doaj.org/article/cdd3b372fae54cabac2d33ab6573fd03
Autor:
Florez Vargas, Oscar, Flórez-Vargas, Oscar, Brass, Andy, Karystianis, George, Bramhall, Michael, Stevens, Robert, Cruickshank, Sheena, Nenadic, Goran
Publikováno v:
eLife, Vol 5 (2016)
eLife
Florez Vargas, O, Flórez-Vargas, O, Brass, A, Karystianis, G, Bramhall, M, Stevens, R, Cruickshank, S & Nenadic, G 2016, ' Bias in the reporting of sex and age in biomedical research on mouse models ', eLife, vol. 5, no. 0, e13615 . https://doi.org/10.7554/eLife.13615
eLife
Florez Vargas, O, Flórez-Vargas, O, Brass, A, Karystianis, G, Bramhall, M, Stevens, R, Cruickshank, S & Nenadic, G 2016, ' Bias in the reporting of sex and age in biomedical research on mouse models ', eLife, vol. 5, no. 0, e13615 . https://doi.org/10.7554/eLife.13615
In animal-based biomedical research, both the sex and the age of the animals studied affect disease phenotypes by modifying their susceptibility, presentation and response to treatment. The accurate reporting of experimental methods and materials, in
Akademický článek
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Autor:
Drude NI; Department of Experimental Neurology, Charité-Universitätsmedizin, Berlin, Germany.; BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany., Martinez Gamboa L; Department of Experimental Neurology, Charité-Universitätsmedizin, Berlin, Germany.; BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany., Danziger M; Department of Experimental Neurology, Charité-Universitätsmedizin, Berlin, Germany.; BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany., Dirnagl U; Department of Experimental Neurology, Charité-Universitätsmedizin, Berlin, Germany.; BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany., Toelch U; BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany.
Publikováno v:
ELife [Elife] 2021 Jan 12; Vol. 10. Date of Electronic Publication: 2021 Jan 12.
Autor:
London AJ; Department of Philosophy and Center for Ethics and Policy, Carnegie Mellon University, Pittsburgh, United States., Kimmelman J; Studies of Translation, Ethics and Medicine Research Group, Biomedical Ethics Unit, McGill University, Montréal, Canada.
Publikováno v:
ELife [Elife] 2015 Nov 24; Vol. 4, pp. e12844. Date of Electronic Publication: 2015 Nov 24.